Roles of the first-generation claudin binder, Clostridium perfringens enterotoxin, in the diagnosis and claudin-targeted treatment of epithelium-derived cancers

2016/09/15 by Yosuke Hashimoto, Kiyohito Yagi, Masuo Kondoh · 18 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Bacteria #Barrier Structure and Function Studies #Biology #Cancer #Cancer research #Cell biology #Claudin #Clostridium perfringens #Enterotoxin #Epithelial ovarian cancer #Epithelium #Gene #Genetics #Gut microbiota and health #Internal medicine #Intestinal epithelium #Medicine #Neurological Disease Mechanisms and Treatments #Ovarian cancer #Pathology #Targeted therapy #Tight junction

paper · doi:10.1007/s00424-016-1878-6

openalex publication_date 2016/09/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Cited by

• Claudins: vital partners in transcellular and paracellular transport coupling
• In silico design of a novel chimeric shigella IpaB fused to C terminal of clostridium perfringens enterotoxin as a vaccine candidate. [europepmc]
• Identification of claudin-4 binder that attenuates tight junction barrier function by TR-FRET-based screening assay. [europepmc]
• Potential for Tight Junction Protein-Directed Drug Development Using Claudin Binders and Angubindin-1. [europepmc]
• Use of Modified Clostridium perfringens Enterotoxin Fragments for Claudin Targeting in Liver and Skin Cells. [europepmc]
• Effects of cLFchimera peptide on intestinal morphology, integrity, microbiota, and immune cells in broiler chickens challenged with necrotic enteritis. [europepmc]
• Tight Junction Modulating Bioprobes for Drug Delivery System to the Brain: A Review. [europepmc]
• Highlighting membrane protein structure and function: A celebration of the Protein Data Bank. [europepmc]
• [A review on the effect of Claudin-18 on bronchopulmonary dysplasia in preterm infants]. [europepmc]
• Ovarian Cancer and Cancer Stem Cells-Cellular and Molecular Characteristics, Signaling Pathways, and Usefulness as a Diagnostic Tool in Medicine and Oncology. [europepmc]
• Do Bacteria Provide an Alternative to Cancer Treatment and What Role Does Lactic Acid Bacteria Play? [europepmc]
• cCPE Fusion Proteins as Molecular Probes to Detect Claudins and Tight Junction Dysregulation in Gastrointestinal Cell Lines, Tissue Explants and Patient-Derived Organoids. [europepmc]
• Antibody-mediated targeting of Claudins in cancer. [europepmc]
• Structural and biophysical insights into targeting of claudin-4 by a synthetic antibody fragment. [europepmc]
• Expression and Targeted Application of Claudins Family in Hepatobiliary and Pancreatic Diseases. [europepmc]
• Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4. [europepmc]
• Key Signals Produced by Gut Microbiota Associated with Metabolic Syndrome, Cancer, Cardiovascular Diseases, and Brain Functions. [europepmc]
• Phenolic Compounds of Grape Pomace Skin Released During SHIME Colonic Fermentation Shape the Transcriptomic Profile of Tight Junctions, Improving the Barrier Properties in Caco-2 Cells. [europepmc]