2025/04/30 by Rettenmeier, Albert W., Drexler, Hans, Hartwig, Andrea +1
#2-dicarboxylat #2-dicarboxylate #5-OH-MEHP #5-cx-MEPP #5-oxo-MEHP #571.95 Toxicology #571.95 Toxikologie #616.9803 Betriebs- und Arbeitsmedizin #616.9803 Industrial and occupational medicine #Arbeitsstoff #BLW #Beurteilungswert #Biologischer Leitwert #Biomonitoring #Bis(2-ethylhexyl)benzol-1 #Bis(2-ethylhexyl)phthalat #DEHP #Di(2-ethylhexyl)phthalat #Gefahrstoff #MEHP #Mono-(2-ethyl-5-carboxypentyl)phthalat #Mono-(2-ethyl-5-hydroxyhexyl)phthalat #Mono-(2-ethyl-5-oxohexyl)phthalat #Mono-(2-ethyl-5-oxyhexyl)phthalat #Mono-(2-ethylhexyl)phthalat #Phthalsäuredi(2-ethylhexyl)ester #Toxizität #Urin #assessment value #berufliche Exposition #biological guidance value #biomonitoring #bis(2-ethylhexyl) benzene-1 #bis(2-ethylhexyl) phthalate #di(2-ethylhexyl) phthalate #hazardous substance #mono-(2-ethyl-5-carboxypentyl) phthalate #mono-(2-ethyl-5-hydroxyhexyl) phthalate #mono-(2-ethyl-5-oxohexyl) phthalate #mono-(2-ethyl-5-oxyhexyl) phthalate #mono-(2-ethylhexyl) phthalate #occupational exposure #phthalic acid di(2-ethylhexyl) ester #substance in the work area #toxicity #urine
paper · doi:10.34865/bb11781e2319_w
The German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area evaluated di(2‐ethylhexyl) phthalate [CAS No. 118‐81‐7] in 2017 and derived a biological guidance value at the workplace (BLW) for the combined urinary concentration of the four major DEHP metabolites mono(2‐ethylhexyl) phthalate (MEHP), mono(2‐ethyl‐5‐hydroxyhexyl) phthalate (5‐OH‐MEHP), mono(2‐ethyl‐5‐oxohexyl) phthalate (5‐oxo‐MEHP) and mono(2‐ethyl‐5‐carboxypentyl) phthalate (5‐cx‐MEPP). Available publications are described in detail. Human studies are not available for deriving a quantitative relationship between the internal dose and the critical toxic effects of DEHP (tumour promotion in the liver, respiratory effects, reproductive and developmental toxicity). Therefore, the evaluation of the BLW was based on the relationship between DEHP uptake by inhalation at the level of the MAK value and the urinary excretion rates of MEHP, 5‐OH‐MEHP, 5‐oxo‐MEHP and 5‐cx‐MEPP, using a conversion factor that defines this relationship. In accordance with this conversion factor external exposure to DEHP at the level of the MAK value corresponds to a combined urinary concentration of the four metabolites of approx. 4 mg/g creatinine at steady state. As the conversion factor has been derived from oral DEHP uptake and metabolite excretion data of only one male volunteer, the concentration of 4 mg/g creatinine is considered a BLW. Sampling time is for long‐term exposure at the end of the shift after several shifts.