1985/10/01 by N.C. Sangster, Nicholas C. Sangster, Roger K. Prichard +1
Agricultural and Biological Sciences · Veterinary · #Nematode management and characterization studies #Helminth infection and control #Insect Pest Control Strategies
paper · doi:10.2307/3281438
Benzimidazole treatment produced greater effects on microtubule-dependent acetylcholinesterase secretion, the presence of microtubules in intestinal cells, and colchicine binding in susceptible compared with benzimidazole-resistant Trichostrongylus colubriformis. In addition, the binding of benzimidazoles was markedly reduced in preparations from the latter strain, indicating that the mechanism of resistance to benzimidazoles in this nematode involves a reduced affinity of tubulin for benzimidazoles.