Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis

2024/11/27 by Lucy MacDonald, Aziza Elmesmari, Domenico Somma +33 · 1 voice · 56 citations
Immunology and Microbiology · Medicine · #Arthritis #Biology #CAR-T cell therapy research #Cell #Cell Adhesion Molecules Research #Cell biology #Dendritic cell #Function (biology) #Genetics #Immune system #Immunology #Immunotherapy and Immune Responses #Myeloid #Niche #Rheumatoid arthritis

paper · doi:10.1016/j.immuni.2024.11.004

published in Immunity 57(12), 2843-2862.e12 (Cell Press)

openalex publication_date 2024/11/27 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06

Abstract

DC2s, which interacted with naive T cells, potentially driving the local expansion of new effector T cells. Remission saw the resolution of these pathogenic niches but lacked recovery of tolerogenic DC2s and exhibited activation of blood precursors of ST-DC3 clusters prior to flare-ups. Targeting pathogenic DC3s or restoring tolerogenic DC2s may help restore immune homeostasis in RA joints.

Citations

• The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis
• EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2022 update
• RNA velocity of single cells

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Discussions

• So happy to (finally!!) announce that our paper studying synovial tissue dendritic cells in joint health and rheumatoid arthritis is now out in Immunity! 🚨 doi.org/10.1016/j.im... [bsky, 57 points, 3 comments]

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