2024/10/21 by Sarwan Ali, Prakash Chourasia, Ali, Sarwan +6
Biochemistry, Genetics and Molecular Biology · #FOS: Computer and information sciences #Gene expression and cancer classification #Genetics, Bioinformatics, and Biomedical Research #Human-Computer Interaction (cs.HC) #Machine Learning (cs.LG) #Machine Learning (stat.ML) #Machine Learning in Bioinformatics
paper · pdf · doi:10.48550/arxiv.2410.15688
openalex publication_date 2024/10/21 · openalex created_date 2024/11/06 · openalex updated_date 2026/07/28
The t-Distributed Stochastic Neighbor Embedding (t-SNE) has emerged as a popular dimensionality reduction technique for visualizing high-dimensional data. It computes pairwise similarities between data points by default using an RBF kernel and random initialization (in low-dimensional space), which successfully captures the overall structure but may struggle to preserve the local structure efficiently. This research proposes a novel approach called the Modified Isolation Kernel (MIK) as an alternative to the Gaussian kernel, which is built upon the concept of the Isolation Kernel. MIK uses adaptive density estimation to capture local structures more accurately and integrates robustness measures. It also assigns higher similarity values to nearby points and lower values to distant points. Comparative research using the normal Gaussian kernel, the isolation kernel, and several initialization techniques, including random, PCA, and random walk initializations, are used to assess the proposed approach (MIK). Additionally, we compare the computational efficiency of all 3 kernels with 3 different initialization methods. Our experimental results demonstrate several advantages of the proposed kernel (MIK) and initialization method selection. It exhibits improved preservation of the local and global structure and enables better visualization of clusters and subclusters in the embedded space. These findings contribute to advancing dimensionality reduction techniques and provide researchers and practitioners with an effective tool for data exploration, visualization, and analysis in various domains.