Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region

2024/06/25 by Aitor Morales-Gregorio, Anno C. Kurth, Junji Ito +5 · 2 voices · 3 citations
Neuroscience · #Neural dynamics and brain function #Neuroscience and Neuropharmacology Research #Neuroscience and Neural Engineering

paper · doi:10.1016/j.celrep.2024.114371

Abstract

High-dimensional brain activity is often organized into lower-dimensional neural manifolds. However, the neural manifolds of the visual cortex remain understudied. Here, we study large-scale multi-electrode electrophysiological recordings of macaque (Macaca mulatta) areas V1, V4, and DP with a high spatiotemporal resolution. We find that the population activity of V1 contains two separate neural manifolds, which correlate strongly with eye closure (eyes open/closed) and have distinct dimensionalities. Moreover, we find strong top-down signals from V4 to V1, particularly to the foveal region of V1, which are significantly stronger during the eyes-open periods. Finally, in silico simulations of a balanced spiking neuron network qualitatively reproduce the experimental findings. Taken together, our analyses and simulations suggest that top-down signals modulate the population activity of V1. We postulate that the top-down modulation during the eyes-open periods prepares V1 for fast and efficient visual responses, resulting in a type of visual stand-by state.

Cited by

• What are the functions of primary visual cortex (V1)?
• Deep Learning–Based Control of Electrically Evoked Activity in Human Visual Cortex
• Cell-type-specific coupling of single-unit spikes and cortical ripples in macaque and human V1

Discussions

• If you are interested in neural manifolds, dimensionality, brain states, and/or top-down modulation you are gonna like this one! 🧠🙈💫🧪 "Neural manifolds in V1 change with top-down signals from V4 [bsky, 82 points, 1 comments]
• Neural manifolds in V1 change with top-down signals from V4 targeting the foveal region doi.org/10.1016/j.ce... #neuroscience [bsky, 3 points, 0 comments]

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