The mechanism of amyloid fibril growth from Φ-value analysis

2025/01/16 by Jacob Aunstrup Larsen, Abigail Barclay, Nicola Vettore +7 · 1 voice · 2 citations
Medicine · Biochemistry, Genetics and Molecular Biology · Materials Science · #Alzheimer's disease research and treatments #Protein Structure and Dynamics #Enzyme Structure and Function

paper · doi:10.1038/s41557-024-01712-9

Citations

• Polymorphic transitions in single crystals: A new molecular dynamics method
• PLUMED 2: New feathers for an old bird

Cited by

• Energetic profiling reveals thermodynamic principles underlying amyloid fibril maturation
• Structural defects in amyloid-β fibrils drive secondary nucleation

Discussions

• How do proteins mis-fold? Paper led by Jacob Aunstrup from Alex Büll’s lab with MD simulations by Abigail Barclay, and key contributions from several others. We combined measurements of Φ-values with [bsky, 91 points, 1 comments]