A human brain vascular atlas reveals diverse mediators of Alzheimer’s risk

2022/02/14 by Andrew C. Yang, Ryan T. Vest, Fabian Kern +25 · 1 voice · 815 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Neuroscience · #Barrier Structure and Function Studies #Biology #Brain atlas #Disease #Endothelial stem cell #Genetics #Human brain #Medicine #Mural cell #Neurodegeneration #Neuroinflammation and Neurodegeneration Mechanisms #Neuroscience #Pathology #Single-cell and spatial transcriptomics

paper · pdf · doi:10.1038/s41586-021-04369-3

published in Nature 603(7903), 885-892 (Nature Portfolio)

openalex publication_date 2022/02/14 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06

Citations

• Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris
• A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules

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• Protective exercise responses in the dentate gyrus of Alzheimer’s disease mouse model revealed with single-nucleus RNA-sequencing
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• The Dementia SomaSignal Test (dSST): A plasma proteomic predictor of 20‐year dementia risk
• What is a cell type and how to define it? [europepmc]
• Vascular endothelial cell development and diversity. [europepmc]
• Human cerebral organoids - a new tool for clinical neurology research. [europepmc]
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• Brain borders at the central stage of neuroimmunology. [europepmc]
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• Perivascular cells induce microglial phagocytic states and synaptic engulfment via SPP1 in mouse models of Alzheimer's disease. [europepmc]
• Advancing cell therapy for neurodegenerative diseases. [europepmc]
• Applications of single-cell RNA sequencing in drug discovery and development. [europepmc]
• Single-nucleus multiregion transcriptomic analysis of brain vasculature in Alzheimer's disease. [europepmc]
• Role of neuroinflammation in neurodegeneration development. [europepmc]
• Atlas of the aging mouse brain reveals white matter as vulnerable foci. [europepmc]
• Epigenomic dissection of Alzheimer's disease pinpoints causal variants and reveals epigenome erosion. [europepmc]
• A comparative atlas of single-cell chromatin accessibility in the human brain. [europepmc]
• Transcriptomic cytoarchitecture reveals principles of human neocortex organization. [europepmc]
• Blood-Brain Barrier Breakdown in Alzheimer's Disease: Mechanisms and Targeted Strategies. [europepmc]
• Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia. [europepmc]
• Organ aging signatures in the plasma proteome track health and disease. [europepmc]
• Cell type-specific roles of APOE4 in Alzheimer disease. [europepmc]
• Cerebrospinal fluid proteomics in patients with Alzheimer's disease reveals five molecular subtypes with distinct genetic risk profiles. [europepmc]
• Microbiota-gut-brain axis and its therapeutic applications in neurodegenerative diseases. [europepmc]
• Single-cell atlas of the human brain vasculature across development, adulthood and disease. [europepmc]
• Cellular communities reveal trajectories of brain ageing and Alzheimer's disease. [europepmc]
• Integrated multimodal cell atlas of Alzheimer's disease. [europepmc]
• Neuroinflammation in Alzheimer disease. [europepmc]

Discussions

• Hard to believe that these photos represent brain samples from 8 different healthy donors. #ImageForensics Published in Nature, 2022. Cited 449 times according to Dimensions. doi.org/10.1038/s415... [bsky, 100 points, 5 comments]