Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes

2025/05/01 by Charlotte M. Delvaux de Fenffe, Jolijn Govers, Francesca Mattiroli · 1 voice · 10 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Biochemistry #Biology #Chemistry #Chromatin #Computational biology #Computer science #DNA #Dynamics (music) #Genomics and Chromatin Dynamics #Physics #RNA Research and Splicing #RNA and protein synthesis mechanisms

paper · open access · doi:10.1021/acs.biochem.5c00114

published in Biochemistry 64(10), 2138-2153 (American Chemical Society)

openalex publication_date 2025/05/01 · openalex created_date 2025/05/02 · openalex updated_date 2026/08/06

Abstract

Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and function. How nucleosomes enable these processes is an active area of study. In this review, we provide an overview of chromatin dynamics, its properties, mechanisms, and functions. We highlight the diverse ways by which chromatin dynamics is controlled during transcription, DNA replication, and repair. Recent technological developments have promoted discoveries in this area, to which we provide an outlook on future research directions.

Citations

• Mechanisms of Inheritance of Chromatin States: From Yeast to Human

Cited by

• Functional Integration of the Bacteriophage T4 DNA Replication Complex: The Multiple Roles of the ssDNA Binding Protein (gp32). [europepmc]
• Hydropathy Landscapes of Histone-DNA Interactions in Chromatin Building Blocks. [europepmc]
• Investigating Phase Separation in Genome Folding via Multiscale Computational Modeling. [europepmc]
• Plasma histone monomers as novel diagnostic markers in adult glioblastoma. [europepmc]

Discussions

• Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, repl [bsky, 107 points, 2 comments]

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• The shifting paradigm of chromatin structure: from the 30-nm chromatin fiber to liquid-like organization
• Genome organization across scales: mechanistic insights from in vitro reconstitution studies
• Chromatin-remodeling for transcription
• Nucleosome positioning and gene regulation