1991/12/01 by J. J. Strain
Medicine · #Nutritional Studies and Diet #Nutrition and Health in Aging #Folate and B Vitamins Research
paper · pdf · doi:10.1079/pns19910073
Oxidants or reactive oxygen species (ROS) have been implicated in the pathology of a number of human diseases including insulin-dependent diabetes mellitus (IDDM) and non-isulin-dependent diabetes mellitus (NIDDM). Sato et al . (1979) were the first to report increased levels of plasma thiobarbituric acid-reactive substances (TBARS), a putative measure of ROS-induced lipid peroxidative damage, in IDDM and NIDDM patients. Subsequent studies have confirmed this observation of increased lipid peroxides in blood from NIDDM (Kaji et af. 1985; Uzel et 01. 1987) and IDDM (Jongkind et al. 1989) patients and in various tissues from rats with streptozotocin (STZ)-or alloxaninduced diabetes (Higuichi, 1982; Karpen et al. 1982; Matkovics et ul. 1982).