Long-term brain and behavioral consequences of early iron deficiency

2011/11/01 by Michael K Georgieff, Michael Georgieff · 298 citations
Medicine · Neuroscience · #Anemia #Biology #Brain Structure and Function #Brain function #Dopamine #Endocrinology #Folate and B Vitamins Research #Hemoglobinopathies and Related Disorders #Hippocampal formation #Internal medicine #Iron Metabolism and Disorders #Iron deficiency #Medicine #Neuroimaging #Neuroscience #Physiology #Term (time)

paper · pdf · doi:10.1111/j.1753-4887.2011.00432.x

published in Nutrition Reviews 69, S43-S48 (Oxford University Press)

openalex publication_date 2011/11/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/01

Abstract

Early iron deficiency not only affects brain and behavioral function during the period of iron deficiency, it persists long after treatment. The mechanisms include long-term alterations in dopamine metabolism, myelination, and hippocampal structure and function. Recent studies have demonstrated long-term genomic changes, which suggests the regulation of brain function is fundamentally altered.

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