Adrenal Insufficiency
1996/10/17 by Wolfgang Oelkers, W. Oelkers · 748 citations
Medicine · Neuroscience · #Adrenal Hormones and Disorders #Adrenal cortex #Adrenal insufficiency #Adrenocorticotropic hormone #Anterior pituitary #Arginine #Biology #Corticotropin-releasing hormone #Endocrinology #Growth Hormone and Insulin-like Growth Factors #Hormone #Hypothalamus #Internal medicine #Medicine #Pituitary gland #Secretion #Stress Responses and Cortisol #Vasopressin
paper · doi:10.1056/nejm199610173351607
published in New England Journal of Medicine 335(16), 1206-1212 (Massachusetts Medical Society)
openalex publication_date 1996/10/17 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31
Abstract
The hypothalamic–pituitary–adrenal axis has an important role in the body's ability to cope with stresses such as infections, hypotension, and surgery. The hypothalamus is subject to regulatory influences from other parts of the brain, especially the limbic system. The hypothalamic hormones corticotropin-releasing hormone and arginine vasopressin are important stimulants of corticotropin secretion by the anterior pituitary. In this gland, the action of the hypothalamic hormones is amplified so that a much larger number of corticotropin molecules is secreted. Similarly, in the adrenal cortex the action of corticotropin is amplified; a plasma corticotropin concentration of approximately 25 pg per milliliter (5.5 . . .
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