Functional Brown Adipose Tissue in Healthy Adults
2009/04/08 by Kirsi A. Virtanen, Martin E. Lidell, Janne Orava +9 · 21 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Adipose Tissue and Metabolism #Muscle metabolism and nutrition #Lipid metabolism and biosynthesis
paper · pdf · doi:10.1056/nejmoa0808949
Abstract
Using positron-emission tomography (PET), we found that cold-induced glucose uptake was increased by a factor of 15 in paracervical and supraclavicular adipose tissue in five healthy subjects. We obtained biopsy specimens of this tissue from the first three consecutive subjects and documented messenger RNA (mRNA) and protein levels of the brown-adipocyte marker, uncoupling protein 1 (UCP1). Together with morphologic assessment, which showed numerous multilocular, intracellular lipid droplets, and with the results of biochemical analysis, these findings document the presence of substantial amounts of metabolically active brown adipose tissue in healthy adult humans.
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