Kynurenine pathway metabolism and the microbiota-gut-brain axis

2016/07/06 by P.J. Kennedy, Paul J. Kennedy, John F. Cryan +4 · 722 citations
Biochemistry, Genetics and Molecular Biology · Neuroscience · Psychology · #Biochemistry #Bioinformatics #Biology #Central nervous system #Gut flora #Gut microbiota and health #Gut–brain axis #Immunology #Kynurenine #Kynurenine pathway #Microbiome #Neuroendocrine regulation and behavior #Neuroscience #Tryptophan #Tryptophan and brain disorders

paper · open access · doi:10.1016/j.neuropharm.2016.07.002

published in Neuropharmacology 112(Pt B), 399-412 (Elsevier BV)

openalex publication_date 2016/07/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06

Citations

• The kynurenine pathway as a therapeutic target in cognitive and neurodegenerative disorders
• An iontophoretic investigation of the actions of convulsant kynurenines and their interaction with the endogenous excitant quinolinic acid
• Antimicrobial activity of psychotropic drugs
• Adult Hippocampal Neurogenesis Is Regulated by the Microbiome
• Assessment of psychotropic-like properties of a probiotic formulation (Lactobacillus helveticusR0052 andBifidobacterium longumR0175) in rats and human subjects
• Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve
• Diet-induced extinctions in the gut microbiota compound over generations

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• NLRP3 inflammasome-driven pathways in depression: Clinical and preclinical findings
• Harnessing Dietary Tryptophan: Bridging the Gap Between Neurobiology and Psychiatry in Depression Management
• Gut microbiome-mediated epigenetic regulation of brain disorder and application of machine learning for multi-omics data analysis
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• Impact of intestinal disorders on central and peripheral nervous system diseases
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• Tryptophan‐derived serotonin‐kynurenine balance in immune activation and intestinal inflammation
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• The Gut-Brain Axis: How Microbiota and Host Inflammasome Influence Brain Physiology and Pathology. [europepmc]
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• Nutritional Components in Western Diet Versus Mediterranean Diet at the Gut Microbiota-Immune System Interplay. Implications for Health and Disease. [europepmc]
• Tryptophan Metabolism and Gut-Brain Homeostasis. [europepmc]
• A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders. [europepmc]
• The microbiota-gut-brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice. [europepmc]
• Microbiota-derived metabolites as drivers of gut-brain communication. [europepmc]
• Microbiome and tryptophan metabolomics analysis in adolescent depression: roles of the gut microbiota in the regulation of tryptophan-derived neurotransmitters and behaviors in human and mice. [europepmc]
• Signalling cognition: the gut microbiota and hypothalamic-pituitary-adrenal axis. [europepmc]