High seroprevalence of Epstein–Barr virus in children with multiple sclerosis

2006/12/12 by Daniela Pohl, D. Pohl, Bernd Krone +13 · 1 citation
Medicine · #Polyomavirus and related diseases #Multiple Sclerosis Research Studies #Viral-associated cancers and disorders

paper · doi:10.1212/01.wnl.0000247665.94088.8d

Abstract

We studied seroprevalence and concentrations of Epstein-Barr virus (EBV) antibodies in 147 pediatric patients with multiple sclerosis (MS) and paired controls. The children with MS showed a near-complete seropositivity for EBV antibody against virus capsid antigen (98.6% vs 72.1% in controls, p = 0.001) but did not display serologic evidence for a recent EBV infection. EBV antibody concentrations of pediatric patients with MS were significantly higher vs controls.

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• Vaccination as a risk factor for pediatric multiple sclerosis: Insights from a retrospective case–control study

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