Verapamil in the prophylaxis of episodic cluster headache: A double-blind study versus placebo

2000/03/28 by M. Leone, Massimo Leone, D. D’Amico +9 · 234 citations
Medicine · #Alternative medicine #Anesthesia #Anesthesia and Pain Management #Calcium #Cardiology #Cluster headache #Double blind #Internal medicine #Medicine #Migraine #Migraine and Headache Studies #Neurological Complications and Syndromes #Placebo #Verapamil

paper · doi:10.1212/wnl.54.6.1382

published in Neurology 54(6), 1382-1385 (Lippincott Williams & Wilkins)

openalex publication_date 2000/03/28 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30

Abstract

The authors performed a double-blind, double-dummy study to compare the efficacy of verapamil with placebo in the prophylaxis of episodic cluster headache. After 5 days' run-in, 15 patients received verapamil (120 mg tid) and 15 received placebo (tid) for 14 days. The authors found a significant reduction in attack frequency and abortive agents consumption in the verapamil group. Side effects were mild. These findings provide objective evidence for the effectiveness of verapamil in episodic cluster headache prophylaxis.

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