Small bite, large impact–saliva and salivary molecules in the medicinal leech, Hirudo medicinalis

2011/11/08 by Jan-Peter Hildebrandt, Jan‐Peter Hildebrandt, Sarah Lemke · 120 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Veterinary · #Bacteria #Biochemistry #Biology #Blood stream #Capnocytophaga #Coagulation #Ecology #Fibrin #Hemostasis #Hirudo medicinalis #Host (biology) #Immunology #Internal medicine #Leech #Leech Biology and Applications #Medicine #Saliva #Salivary gland #Venomous Animal Envenomation and Studies #Veterinary Pharmacology and Anesthesia

paper · doi:10.1007/s00114-011-0859-z

published in Die Naturwissenschaften 98(12), 995-1008 (Springer Science+Business Media)

openalex publication_date 2011/11/08 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/29

Cited by

• Medicinal leech therapy—an overall perspective
• Quo vadis venomics? A roadmap to neglected venomous invertebrates. [europepmc]
• [Effects of hirudin on the expression of basic fibroblast growth factor and transforming growth factor-β1 in human gingival fibroblasts]. [europepmc]
• Huangzhi Oral Liquid Prevents Arrhythmias by Upregulating Caspase-3 and Apoptosis Network Proteins in Myocardial Ischemia-Reperfusion Injury in Rats. [europepmc]
• A comparison of the enzymatic properties of three recombinant isoforms of thrombolytic and antibacterial protein--Destabilase-Lysozyme from medicinal leech. [europepmc]
• The Effectiveness of Leech Therapy in Chronic Low Back Pain. [europepmc]
• Medicinal leech therapy in venous congestion and various ulcer forms: Perspectives of Western, Persian and Indian medicine. [europepmc]
• European Medicinal Leeches-New Roles in Modern Medicine. [europepmc]
• Draft genome sequences of Hirudo medicinalis and salivary transcriptome of three closely related medicinal leeches. [europepmc]
• The hirudin-like factors HLF3 and HLF4-hidden hirudins of European medicinal leeches. [europepmc]
• Complications of leech therapy. [europepmc]
• Liposomes for Intra-Articular Analgesic Drug Delivery in Orthopedics: State-of-Art and Future Perspectives. Insights from a Systematic Mini-Review of the Literature. [europepmc]
• The Hirudo Medicinalis Microbiome Is a Source of New Antimicrobial Peptides. [europepmc]
• Draft mitochondrial genomes of Hirudo medicinalis and Hirudo verbana (Annelida, Hirudinea). [europepmc]
• Prostaglandin E1 Is an Efficient Molecular Tool for Forest Leech Blood Sucking. [europepmc]
• The genome of medicinal leech (Whitmania pigra) and comparative genomic study for exploration of bioactive ingredients. [europepmc]
• Combined systems pharmacology and fecal metabonomics to study the biomarkers and therapeutic mechanism of type 2 diabetic nephropathy treated with Astragalus and Leech. [europepmc]
• Make it double: identification and characterization of a Tandem-Hirudin from the Asian medicinal leech Hirudinaria manillensis. [europepmc]
• Diversity of hirudin and hirudin-like factor genes in the North-African medicinal leech, Hirudo troctina. [europepmc]
• Chromosome-level genome assembly and anticoagulant protein annotation of the buffalo leech Hirudinaria bpling (Hirudinea: Hirudinidae). [europepmc]
• Comparative Study of Hirudins and Encoding Genes in Hirudo nipponia and Hirudo tianjinensis . [europepmc]
• Duplication of the Antistasin-Like Structure Resulted in a New Anticoagulant Protein in the Medicinal Leech. [europepmc]
• The great diversity: monomeric and oligomeric hirudins, hirudin-like factors and decorsins in the Asian medicinal leeches Hirudo nipponia and Hirudo tianjinensis. [europepmc]
• Medicinal Leech Therapy in Urology: A PRISMA-Compliant Systematic Review. [europepmc]
• Blood Relatives: Linking Evolutionary History and Conservation of Medicinal Leeches ( Hirudo spp.). [europepmc]
• Nasopharyngeal hirudiniasis, a rare cause of masked hemoptysis in an older patient: A case report. [europepmc]