Proteogenomics connects somatic mutations to signalling in breast cancer

2016/05/24 by Philipp Mertins, NCI CPTAC, D. R. Mani +37 · 20 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Cancer Genomics and Diagnostics #Breast Cancer Treatment Studies #Cancer-related Molecular Pathways

paper · doi:10.1038/nature18003

Cited by

• Proteogenomic Characterization Reveals Therapeutic Vulnerabilities in Lung Adenocarcinoma
• Integrative Proteogenomics and Forward Genetics Reveal a Novel Mitotic Vulnerability in Triple-Negative Breast Cancer
• TDP‐43 Phosphorylation: Pathological Modification or Protective Factor Antagonizing TDP‐43 Aggregation in Neurodegenerative Diseases?
• Proteomics Identifies Osteomodulin as a Promoter of Breast Cancer Bone Metastasis via CDK1 Activation
• Challenging the heterogeneity of disease presentation in malignant melanoma—impact on patient treatment
• Clinical protein science in translational medicine targeting malignant melanoma
• NUAK: never underestimate a kinase
• Confounding factors and biases abound when predicting molecular biomarkers from histological images
• Mechanical regulation of glycolysis via cytoskeleton architecture
• mRNAs, proteins and the emerging principles of gene expression control
• ARF6‐Rac1 signaling‐mediated neurite outgrowth is potentiated by the neuronal adaptor FE65 through orchestrating ARF6 and ELMO1
• Structure, biochemistry, and biology of PAK kinases
• Distinguishing post‐translational modifications in dominantly inherited frontotemporal dementias: FTLD‐TDP Type A ( <i>GRN</i> ) vs Type B ( <i>C9orf72</i> )
• Rewriting the cancer proteome: targeting selective translation as a therapeutic frontier
• SynProtX: a large-scale proteomics-based deep learning model for predicting synergistic anticancer drug combinations
• Synthesis and Biological Evaluation of Novel Triazine Analogs as Rad6 Inhibitors
• Mutation impact on mRNA versus protein expression across human cancers
• Pan-cancer analysis identifies tumor-specific antigens derived from transposable elements
• Quantitative Proteomics of the Cancer Cell Line Encyclopedia
• Exploring Strategies for Personalized Radiation Therapy: Part III Identifying genetic determinants for Radiation Response with Meta Learning