Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia

2014/07/11 by Serkan Kır, Serkan Kir, James P. White +5 · 682 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Adipose Tissue and Metabolism #Adipose tissue #Brown adipose tissue #Cachexia #Cancer #Endocrinology #Internal medicine #Lewis lung carcinoma #Medicine #Metastasis #Muscle Physiology and Disorders #Nutrition and Health in Aging #Obesity #Skeletal muscle #Wasting #Wasting Syndrome #Weight loss

paper · doi:10.1038/nature13528

published in Nature 513(7516), 100-104 (Nature Portfolio)

openalex publication_date 2014/07/11 · openalex created_date 2016/06/24 · openalex updated_date 2026/08/03

Cited by

• A neuroimmune circuit mediates cancer cachexia-associated apathy
• Interorgan Communication Pathways in Physiology: Focus on Drosophila
• Cancer-Associated Cachexia: Bridging Clinical Findings with Mechanistic Insights in Human Studies
• Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis
• Bone Marrow Adiposity: Basic and Clinical Implications
• MIF-ACKR3 causes irreversible fat loss by impairing adipogenesis in cancer cachexia
• The impact of hyperparathyroidism on skeletal muscle pathophysiology and physical function
• Pancreatic cancer cachexia: A systemic consequence of multi-organ interactions
• Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics
• Sorting out adipocyte precursors and their role in physiology and disease
• Astrocytic adenosine receptor A2A and Gs-coupled signaling regulate memory. [europepmc]
• Famine versus feast: understanding the metabolism of tumors in vivo. [europepmc]
• Brown and beige fat in humans: thermogenic adipocytes that control energy and glucose homeostasis. [europepmc]
• Systemic organ wasting induced by localized expression of the secreted insulin/IGF antagonist ImpL2. [europepmc]
• Brown and Beige Fat: Physiological Roles beyond Heat Generation. [europepmc]
• PTH/PTHrP Receptor Mediates Cachexia in Models of Kidney Failure and Cancer. [europepmc]
• Mitochondrial ROS regulate thermogenic energy expenditure and sulfenylation of UCP1. [europepmc]
• Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche. [europepmc]
• Interorgan Communication Pathways in Physiology: Focus on Drosophila. [europepmc]
• Tumor induces muscle wasting in mice through releasing extracellular Hsp70 and Hsp90. [europepmc]
• Brown Adipose Tissue: an Update on Recent Findings. [europepmc]
• Accumulation of succinate controls activation of adipose tissue thermogenesis. [europepmc]
• Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases. [europepmc]
• TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma. [europepmc]
• Browning of white fat: agents and implications for beige adipose tissue to type 2 diabetes. [europepmc]
• Structure and dynamics of the active human parathyroid hormone receptor-1. [europepmc]
• Cancer-associated adipocytes: key players in breast cancer progression. [europepmc]
• The β3-adrenergic receptor agonist mirabegron improves glucose homeostasis in obese humans. [europepmc]
• Cancer cachexia and its pathophysiology: links with sarcopenia, anorexia and asthenia. [europepmc]
• Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease. [europepmc]
• Adipocyte lipolysis: from molecular mechanisms of regulation to disease and therapeutics. [europepmc]
• Pathogenesis of sarcopenia and the relationship with fat mass: descriptive review. [europepmc]
• Browning of the white adipose tissue regulation: new insights into nutritional and metabolic relevance in health and diseases. [europepmc]
• Cachexia: A systemic consequence of progressive, unresolved disease. [europepmc]
• Cancer cachexia: molecular mechanisms and treatment strategies. [europepmc]