A single-cell transcriptomic atlas characterizes ageing tissues in the mouse
2020/07/15 by Nicole Almanzar, Jane Antony, Ankit S. Baghel +148 · 1,347 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · Neuroscience · #Ageing #Biology #Cell #Cell biology #Cell type #Computational biology #Gene #Gene expression #Genetics #Immune cells in cancer #Neuroinflammation and Neurodegeneration Mechanisms #Single-cell and spatial transcriptomics #Transcriptome
paper · open access · doi:10.1038/s41586-020-2496-1
published in Nature 583(7817), 590-595 (Nature Portfolio)
openalex publication_date 2020/07/15 · openalex created_date 2021/07/19 · openalex updated_date 2026/08/04
Citations
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- Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice
- Plasma proteomic signatures of cellular aging predict human disease
- Ageing limits stemness and tumorigenesis by reprogramming iron homeostasis
- Comprehensive analysis of multiple species identifies novel molecular signatures and pathways involved in aging
- A metabolic atlas of mouse aging
- Hallmarks of aging: An expanding universe
- MOFA-FLEX: A Factor Model Framework for Integrating Omics Data with Prior Knowledge
- Synaptic pruning through glial synapse engulfment upon motor learning
- Glia inflammation and cell death pathways drive disease progression in preclinical and early AD
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- Avian lung single-cell atlas elucidates evolutionary divergence in endothermic respiration
- Transcriptomics Analysis Identifies the Decline in the Alveolar Type II Stem Cell Niche in Aged Human Lungs
- Aged murine bone marrow myeloid and mesenchymal cells develop unique senescence phenotypes
- Under the Shadow: Old-biased Genes Are Subject to Weak Purifying Selection at Both the Tissue- and Cell Type-Specific Levels
- A transcriptome-based human universal senescence index (hUSI) robustly predicts cellular senescence under various conditions
- Pedoman Peri-operatif Renal Assessment
- Mitochondrial respiration atlas reveals differential changes in mitochondrial function across sex and age
- The systemic costs of hematopoietic stem cell aging
- Aging represses oncogenic KRAS-driven lung tumorigenesis and alters tumor suppression
- scUnified: An AI-Ready Standardized Resource for Single-Cell RNA Sequencing Analysis
- Biological organ ages associate with risk of chronic diseases in a community-based population
- Inhibiting LSD1 unlocks retinoid AP-1 programming to activate epithelial immunity and skin tumor suppression
- Inhibition of acute lung inflammation by a neuroimmune circuit induced by vagal nerve stimulation
- Tabula Sapiens reveals transcription factor expression, senescence effects, and sex-specific features in cell types from 28 human organs and tissues
- Concept Learners for Few-Shot Learning
- cGAS–STING drives ageing-related inflammation and neurodegeneration
- Universal transcriptomic hallmarks of mammalian ageing and mortality
- The CD8 + immgenT framework as a universal reference of mouse CD8αβ T cell differentiation states
- Single‐Cell and Spatial Multiomics: Applications for Diseases
- Unexpected XIST Expression in Male Hearts Associates with Disease
- GRHL and PGR control WNT4 expression via 3D looping of conserved and species-specific enhancers
- Restoring information in aged gene regulatory networks by single knock-ins
- Spatiotemporal transcriptomic niches of complement pathway and serine protease inhibitor activation in aging and infection
- GeneSetCart: assembling, augmenting, combining, visualizing, and analyzing gene sets
- Life-long microbiome rejuvenation improves intestinal barrier function and inflammaging in mice
- Regeneration leads to global tissue rejuvenation in aging sexual planarians
- The cell rejuvenation atlas: leveraging network biology to identify master regulators of rejuvenation strategies
- Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
- Benchmarking atlas-level data integration in single-cell genomics
- Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data
- FUnc-SNE: A flexible, Fast, and Unconstrained algorithm for neighbour embeddings
- Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain
- Single-cell sequencing and organoids: applications in organ development and disease
- Single-cell RNA sequencing profiles age-related transcriptional landscapes in human hair follicle cells
- Soft Graph Clustering for single-cell RNA Sequencing Data
- Identifying Age‐Modulating Compounds Using a Novel Computational Framework for Evaluating Transcriptional Age
- Common Cell type Nomenclature for the mammalian brain: A systematic, extensible convention
- Cryptic mitochondrial DNA mutations coincide with mid-late life and are pathophysiologically informative in single cells across tissues and species
- Aging and aging-related diseases: from molecular mechanisms to interventions and treatments
- An snRNA-seq aging clock for the fruit fly head sheds light on sex-biased aging
- Inferring post-transcriptional regulation within and across cell types in human testis
- Cardiac Molecular Analysis Reveals Aging‐Associated Metabolic Alterations Promoting Glycosaminoglycans Accumulation via Hexosamine Biosynthetic Pathway
- Hepatic stellate cell senescence in liver fibrosis: Characteristics, mechanisms and perspectives
- CellMaster: Collaborative Cell Type Annotation in Single-Cell Analysis
- A neuronal blood marker is associated with mortality in old age
- Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract. [europepmc]
- Capillary cell-type specialization in the alveolus. [europepmc]
- Senescent cells promote tissue NAD + decline during ageing via the activation of CD38 + macrophages. [europepmc]
- A molecular cell atlas of the human lung from single-cell RNA sequencing. [europepmc]
- Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders. [europepmc]
- Dysregulation of brain and choroid plexus cell types in severe COVID-19. [europepmc]
- Mapping single-cell data to reference atlases by transfer learning. [europepmc]
- Immune ageing at single-cell resolution. [europepmc]
- Benchmarking atlas-level data integration in single-cell genomics. [europepmc]
- Mapping transcriptomic vector fields of single cells. [europepmc]
- Adipose-tissue plasticity in health and disease. [europepmc]
- Immunomodulation by endothelial cells - partnering up with the immune system? [europepmc]
- The Tabula Sapiens: A multiple-organ, single-cell transcriptomic atlas of humans. [europepmc]
- Measuring biological age using omics data. [europepmc]
- A new gene set identifies senescent cells and predicts senescence-associated pathways across tissues. [europepmc]
- Polygenic enrichment distinguishes disease associations of individual cells in single-cell RNA-seq data. [europepmc]
- The landscape of aging. [europepmc]
- Aging and aging-related diseases: from molecular mechanisms to interventions and treatments. [europepmc]
- Molecular and spatial signatures of mouse brain aging at single-cell resolution. [europepmc]
- Biomarkers of aging. [europepmc]
- Inflammation and aging: signaling pathways and intervention therapies. [europepmc]
- An atlas of healthy and injured cell states and niches in the human kidney. [europepmc]
- cGAS-STING drives ageing-related inflammation and neurodegeneration. [europepmc]
- Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer's disease pathology. [europepmc]
- Organ aging signatures in the plasma proteome track health and disease. [europepmc]