A single-cell atlas of the airway epithelium reveals the CFTR-rich pulmonary ionocyte

2018/07/31 by Lindsey W. Plasschaert, Rapolas Žilionis, Rayman Choo-Wing +5 · 1,132 citations
Medicine · #Airway #Anatomy #Atlas (anatomy) #Biology #Cell #Epithelium #Genetics #Inhalation and Respiratory Drug Delivery #Medicine #Neonatal Respiratory Health Research #Pathology #Respiratory epithelium #Respiratory viral infections research #Surgery

paper · doi:10.1038/s41586-018-0394-6

published in Nature 560(7718), 377-381 (Nature Portfolio)

openalex publication_date 2018/07/31 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Citations

• Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung
• A revised airway epithelial hierarchy includes CFTR-expressing ionocytes

Cited by

• Transfer learning enables predictions in network biology
• Human distal lung maps and lineage hierarchies reveal a bipotent progenitor
• Evidence of secondary Notch signaling within the rat small intestine
• Single-Cell and Spatial Transcriptomic Profiling Reveals Epithelial Functional States and Fibroblast Phenotypes in Hormone Therapy–Naïve Localized Prostate Cancer
• CFTR as a therapeutic target for severe lung infection
• Dictionary learning for integrative, multimodal and scalable single-cell analysis
• Base editing and nanoparticle transfection of airway cell types essential for treatment of cystic fibrosis
• Negative regulation of human IL-33 in endothelium during allergic airway inflammation
• Single cell transcriptional analysis of human adenoids identifies molecular features of airway microfold cells
• A systems view of cellular heterogeneity: Unlocking the “wheel of fate”
• Specialized gas-exchange endothelium of the zebrafish gill
• The H+-ATPase (V-ATPase): from proton pump to signaling complex in health and disease
• Spatially resolved transcriptomic analysis of the adult human prostate
• Human Body Single-Cell Atlas of 3D Genome Organization and DNA Methylation
• Multiomics analysis provides insights into musk secretion in muskrat and musk deer
• Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia
• Anomalous Epithelial Variations and Ectopic Inflammatory Response in Chronic Obstructive Pulmonary Disease
• A New Basis for Sparse Principal Component Analysis
• A broad introduction to RNA-Seq
• Human distal airways contain a multipotent secretory cell that can regenerate alveoli
• Long-term expanding human airway organoids for disease modeling. [europepmc]
• Current best practices in single-cell RNA-seq analysis: a tutorial. [europepmc]
• Droplet-based combinatorial indexing for massive-scale single-cell chromatin accessibility. [europepmc]
• Brief update on endocytosis of nanomedicines. [europepmc]
• scRNA-seq assessment of the human lung, spleen, and esophagus tissue stability after cold preservation. [europepmc]
• Lineage tracing on transcriptional landscapes links state to fate during differentiation. [europepmc]
• Lineage tracing meets single-cell omics: opportunities and challenges. [europepmc]
• The Cellular and Physiological Basis for Lung Repair and Regeneration: Past, Present, and Future. [europepmc]
• Regenerative potential of prostate luminal cells revealed by single-cell analysis. [europepmc]
• Cigarette Smoke Exposure and Inflammatory Signaling Increase the Expression of the SARS-CoV-2 Receptor ACE2 in the Respiratory Tract. [europepmc]
• Epithelial cell dysfunction, a major driver of asthma development. [europepmc]
• Epithelial barriers in allergy and asthma. [europepmc]
• Structural cells are key regulators of organ-specific immune responses. [europepmc]
• Single-cell RNA sequencing reveals profibrotic roles of distinct epithelial and mesenchymal lineages in pulmonary fibrosis. [europepmc]
• Non-neuronal expression of SARS-CoV-2 entry genes in the olfactory system suggests mechanisms underlying COVID-19-associated anosmia. [europepmc]
• Regulation of immune responses by the airway epithelial cell landscape. [europepmc]
• Cellular and functional heterogeneity of the airway epithelium. [europepmc]
• SARS-CoV-2 infection of the oral cavity and saliva. [europepmc]
• Impaired local intrinsic immunity to SARS-CoV-2 infection in severe COVID-19. [europepmc]
• Human distal airways contain a multipotent secretory cell that can regenerate alveoli. [europepmc]
• Human distal lung maps and lineage hierarchies reveal a bipotent progenitor. [europepmc]
• Single-nucleus cross-tissue molecular reference maps toward understanding disease gene function. [europepmc]
• Pathogenesis of pneumonia and acute lung injury. [europepmc]
• Dictionary learning for integrative, multimodal and scalable single-cell analysis. [europepmc]
• Transfer learning enables predictions in network biology. [europepmc]