Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex

2020/05/20 by Minrui Fan, Jinru Zhang, Chen-Wei Tsai +6 · 2 citations
Biochemistry, Genetics and Molecular Biology · #Mitochondrial Function and Pathology #ATP Synthase and ATPases Research #Cell death mechanisms and regulation

paper · doi:10.1038/s41586-020-2309-6

Citations

• Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter
• The mitochondrial calcium uniporter is a highly selective ion channel
• X-ray and cryo-EM structures of the mitochondrial calcium uniporter

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• Disrupting the network of co-evolving amino terminal domain residues relieves mitochondrial calcium uptake inhibition by MCUb
• Mitochondrial Calcium Regulation of Cardiac Metabolism in Health and Disease