The relation of recombination to mutational advance
1964/05/01 by H.J. Muller, Hermann J. Müller · 2,674 citations
Agricultural and Biological Sciences · Biochemistry, Genetics and Molecular Biology · #Biology #CRISPR and Genetic Engineering #Chromosomal and Genetic Variations #Demography #Ectopic recombination #Evolution and Genetic Dynamics #Evolutionary biology #Gene #Genetic recombination #Genetics #Mutant #Mutation #Mutation rate #Population #Recombination
paper · doi:10.1016/0027-5107(64)90047-8
published in Mutation research. Fundamental and molecular mechanisms of mutagenesis 1(1), 2-9
openalex publication_date 1964/05/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/30
Citations
Cited by
- Bangiomorpha pubescensn. gen., n. sp.: implications for the evolution of sex, multicellularity, and the Mesoproterozoic/Neoproterozoic radiation of eukaryotes
- Hypothesis that ancestral eukaryotes sexually proliferated without kinetochores or mitosis
- Gain and Loss of Heterozygosity in the Genome of the Asexual Nematode Halicephalobus mephisto
- Agamospermy as a mechanism to maintain species boundaries in sympatric Goodyera species
- Muller’s ratchet in symbiont populations
- Evolutionary Consequences of Unusually Large Pericentric TE-rich Regions in the Genome of a Neotropical Fig Wasp
- Experimental tests on the evolution of sex and recombination and their adaptive significance
- A small polymerase ribozyme that can synthesize itself and its complementary strand
- Repeated Independent Formation of Triploid Lineages Contributes to Clonal Diversity in Heteronotia binoei Parthenogens
- Cracking the meiotic secrets behind animals asexuality: when cytology seduces genomics to decode asexual meiosis
- Reconstructing evolution: Gene transfer from plastids to the nucleus
- An Intrinsic Advantage of Sexual Reproduction
- Chromosomal fusions and evolutionary forces: Exploring the neo-sex chromosome system of Anolis distichus
- HJ Muller and the Relationship Between Sex Chromosome Degeneration and the Evolution of Dosage Compensation
- Island colonization and extinction of an insect species revealed by mitochondrial and genome-wide nuclear variation
- The Tree of Sex consortium: a global initiative for studying the evolution of reproduction in eukaryotes
- Rare sexual reproduction by females of “obligate parthenogenetic” lineages of Daphnia cf. pulex
- Frequent horizontal chromosome transfer between asexual fungal insect pathogens
- Improving Oenococcus oeni to overcome challenges of wine malolactic fermentation
- Genetic diversity and connectivity of deep-sea hydrothermal vent metapopulations
- Solvable senescence model with positive mutations
- The on‐again, off‐again relationship between mitochondrial genomes and species boundaries
- Evolution of Large Polymorphic Inversions in a Panmictic Songbird
- Clonal longevity and the enigmatic flowering of woody bamboos are associated with rates of protein evolution
- The fate of competing beneficial mutations in an asexual population
- Reductive evolution of resident genomes
- Leishmania genomic adaptation: more than just a 36-body problem
- Modified meiosis in the tardigrade Hypsibius exemplaris maintains heterozygosity across the genome
- Evolutionary dynamics of enlarged neo-sex chromosomes and novel pseudoautosomal regions in Sylvioidea songbirds
- Variation in phenotype, genotype, and somatic diversity among asexual Schmidtea mediterranea planarians
- Parthenogenetic populations of the freshwater snailCampeloma limumoccupy habitats with fewer environmental stressors than their sexual counterparts
- Deleterious passengers in adapting populations
- Accumulation of mutations in sexual and asexual populations
- An Illustrated Introduction to the Basic Biological Principles
- The Hypercube of Life: How Protein Stability Imposes Limits on Organism Complexity and Speed of Molecular Evolution
- Limitations of serial cloning in mammals
- A Dual Role for Sex?
- Reduced Mitochondrial Respiration in Hybrid Asexual Lizards
- Fluctuations of fitness distributions and the rate of Muller's ratchet
- Recombination and the role of pseudo-overdominance in polyploid evolution
- Finite genome size can halt Muller's ratchet
- Mathematical modeling of evolution of horizontally transferred genes
- Large-scale genomic analysis reveals recurrent patterns of intertypic recombination in human enteroviruses
- Evolution and maintenance of mtDNA gene content across eukaryotes
- Rapid fixation of deleterious alleles can be caused by Muller's ratchet
- Rare beneficial mutations can halt Muller's ratchet
- Molecular Labor Division: Its Cause and Consequence
- MPL resolves genetic linkage in fitness inference from complex evolutionary histories
- Molecular evolutionary trends and biosynthesis pathways in the Oribatida revealed by the genome of Archegozetes longisetosus
- Reproductive success, spontaneous embryo abortion, and genetic load in flowering plants
- Holes in the Hologenome: Why Host-Microbe Symbioses Are Not Holobionts
- Viral quasispecies
- Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos
- Cancer cells employ an evolutionarily conserved polyploidization program to resist therapy
- Paradoxes of cancer: Survival at the brink
- Quasispecies theory for horizontal gene transfer and recombination
- The Evolutionary Enigma of Sex
- Symbiosis of Thioautotrophic Bacteria with Riftia pachyptila
- The Genetic Diversification of a Single Bluetongue Virus Strain Using an In Vitro Model of Alternating-Host Transmission
- Evolution experiments with microorganisms: the dynamics and genetic bases of adaptation
- Evolution of Sex: Why Do Organisms Shuffle Their Genotypes?
- Transmission of Bacterial Symbionts With and Without Genome Erosion Between a Beetle Host and the Plant Environment
- Genome evolution in bacterial endosymbionts of insects
- The Ingenuity of Bacterial Genomes
- Weird Animal Genomes and the Evolution of Vertebrate Sex and Sex Chromosomes
- Taxonomy and Biogeography of Apomixis in Angiosperms and Associated Biodiversity Characteristics
- The advantage of recombination when selection is acting at many genetic Loci
- Mutational fitness effects in RNA and single-stranded DNA viruses: common patterns revealed by site-directed mutagenesis studies
- Quantifying the genomic decay paradox due to Muller's ratchet in human mitochondrial DNA
- Distribution of fitness effects caused by random insertion mutations in Escherichia coli
- A quasispecies approach to the evolution of sexual replication in unicellular organisms
- RNA VIRUS MUTATIONS AND FITNESS FOR SURVIVAL
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- Masking of Mutations and the Evolution of Sex
- Thelytokous parthenogenesis in the damselfly Ischnura hastata (Odonata, Coenagrionidae): genetic mechanisms and lack of bacterial infection
- The new biology: beyond the Modern Synthesis
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- The architecture of the life cycle in small organisms
- The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation
- Basic concepts in RNA virus evolution
- Traffic Flow on Networks
- Evolutionary dynamics of the chromatophore genome in three photosynthetic Paulinella species
- What Is a Quasispecies?
- Eukaryotic microbes, species recognition and the geographic limits of species: examples from the kingdom Fungi
- Ecological and evolutionary opportunities of apomixis: insights from Taraxacum and Chondrilla
- Stochastic Tunneling and Metastable States During the Somatic Evolution of Cancer
- Sex: Advantage
- Why have sex? The population genetics of sex and recombination
- Interspecific hybridization in plant‐associated fungi and oomycetes: a review
- Evolutionary Origins and Ecological Consequences of Endophyte Symbiosis with Grasses
- Origin and evolution of the mitochondrial proteome. [europepmc]
- Clonal origin and evolution of a transmissible cancer. [europepmc]
- The traveling-wave approach to asexual evolution: Muller's ratchet and speed of adaptation. [europepmc]
- The causes of mutation accumulation in mitochondrial genomes. [europepmc]
- Design and engineering of an O(2) transport protein. [europepmc]
- Outcrossing and the maintenance of males within C. elegans populations. [europepmc]
- Mutational fitness effects in RNA and single-stranded DNA viruses: common patterns revealed by site-directed mutagenesis studies. [europepmc]
- Horizontal gene transfer between bacteria and animals. [europepmc]
- Coronaviruses: an RNA proofreading machine regulates replication fidelity and diversity. [europepmc]
- Why do RNA viruses recombine? [europepmc]
- Somatic mutations in aging, cancer and neurodegeneration. [europepmc]
- Holes in the Hologenome: Why Host-Microbe Symbioses Are Not Holobionts. [europepmc]
- Genetic Drift during Systemic Arbovirus Infection of Mosquito Vectors Leads to Decreased Relative Fitness during Host Switching. [europepmc]
- RNA Recombination Enhances Adaptability and Is Required for Virus Spread and Virulence. [europepmc]
- Host specialization of the blast fungus Magnaporthe oryzae is associated with dynamic gain and loss of genes linked to transposable elements. [europepmc]
- The on-again, off-again relationship between mitochondrial genomes and species boundaries. [europepmc]
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- Segregation of mitochondrial DNA heteroplasmy through a developmental genetic bottleneck in human embryos. [europepmc]
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- Mitochondrial function in development and disease. [europepmc]
- Effects of Selection at Linked Sites on Patterns of Genetic Variability. [europepmc]