Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity

2017/11/21 by Yi Lu, Weili Zheng, Shengchen Lin +7 · 15 citations
Chemistry · Medicine · #Bile acid #Biochemistry #Chemistry #Drug Transport and Resistance Mechanisms #Farnesoid X receptor #Ligand (biochemistry) #Medicine #Natural Compounds in Disease Treatment #Nuclear receptor #Oleanolic acid #Pharmacological Effects of Medicinal Plants #Receptor #Stereochemistry #Transcription factor

paper · pdf · doi:10.1124/mol.117.109900

openalex publication_date 2017/11/21 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/26

Cited by

• Oleanolic Acid-amino Acids Derivatives: Design, Synthesis, and Hepatoprotective Evaluation In Vitro and In Vivo. [europepmc]
• Update on FXR Biology: Promising Therapeutic Target? [europepmc]
• Bile-ology: from bench to bedside. [europepmc]
• Anti-Inflammatory Activity of Diterpenoids from Celastrus orbiculatus in Lipopolysaccharide-Stimulated RAW264.7 Cells. [europepmc]
• Improving glucose and lipids metabolism: drug development based on bile acid related targets. [europepmc]
• Transcriptome study of oleanolic acid in the inhibition of breast tumor growth based on high-throughput sequencing. [europepmc]
• Bile Acid-Mediated Activation of Brown Fat Protects From Alcohol-Induced Steatosis and Liver Injury in Mice. [europepmc]
• Natural Products Targeting Liver X Receptors or Farnesoid X Receptor. [europepmc]
• Hepatic SIRT6 Modulates Transcriptional Activities of FXR to Alleviate Acetaminophen-induced Hepatotoxicity. [europepmc]
• Natural Product 2-Oxokolavenol Is a Novel FXR Agonist. [europepmc]
• A Review of Herbal Resources Inducing Anti-Liver Metastasis Effects in Gastrointestinal Tumors via Modulation of Tumor Microenvironments in Animal Models. [europepmc]
• CYP8B1 downregulation mediates the metabolic effects of vertical sleeve gastrectomy in mice. [europepmc]
• Harnessing Oleanolic Acid and Its Derivatives as Modulators of Metabolic Nuclear Receptors. [europepmc]
• Overview of Ursolic Acid Potential for the Treatment of Metabolic Disorders, Autoimmune Diseases, and Cancers via Nuclear Receptor Pathways. [europepmc]
• Antitumour activity of oleanolic acid: A systematic review and meta‑analysis. [europepmc]