Hyperforin-Induced Activation of the Pregnane X Receptor Is Influenced by the Organic Anion-Transporting Polypeptide 2B1

2018/12/20 by Anima M. Schäfer, Olivier Potterat, Isabell Seibert +2 · 27 citations
Agricultural and Biological Sciences · Chemistry · Medicine · Pharmacology, Toxicology and Pharmaceutics · #Biochemistry #Biology #Biophysics #Chemistry #Drug Transport and Resistance Mechanisms #Efflux #Endocrinology #Hyperforin #Hypericum perforatum #Natural Compound Pharmacology Studies #Nuclear receptor #Organic anion-transporting polypeptide #Pharmacogenetics and Drug Metabolism #Pharmacology #Pregnane X receptor #Tibolone #Transcription factor #Transporter

paper · pdf · doi:10.1124/mol.118.114066

published in Molecular Pharmacology 95(3), 313-323 (American Society for Pharmacology and Experimental Therapeutics)

openalex publication_date 2018/12/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Citations

• Interplay between the Nuclear Receptor Pregnane X Receptor and the Uptake Transporter Organic Anion Transporter Polypeptide 1A2 Selectively Enhances Estrogen Effects in Breast Cancer
• St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor
• Transport Function and Transcriptional Regulation of a Liver-Enriched Human Organic Anion Transporting Polypeptide 2B1 Transcriptional Start Site Variant

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