A Novel Multivalent Ligand That Bridges the Allosteric and Orthosteric Binding Sites of the M2 Muscarinic Receptor

2007/05/09 by Tod Steinfeld, Mathai Mammen, Jacqueline A.M. Smith +2
Biochemistry, Genetics and Molecular Biology · Neuroscience · #Receptor Mechanisms and Signaling #Neuropeptides and Animal Physiology #Pharmacological Receptor Mechanisms and Effects

paper · doi:10.1124/mol.106.033746

Citations

• Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction