St. John’s Wort Formulations Induce Rat CYP3A23-3A1 Independent of Their Hyperforin Content

2023/10/20 by Anima M. Schäfer, Marta Rysz, Marta A. Rysz +8 · 5 citations
Agricultural and Biological Sciences · Chemistry · Materials Science · #Biochemistry #Biology #CYP3A4 #Chemistry #Cytochrome P450 #Enzyme #Gene #Hyperforin #Hypericin #Hypericum perforatum #Molecular biology #Natural Compound Pharmacology Studies #Nuclear receptor #Pharmacology #Phytochemistry and Bioactive Compounds #Phytochemistry and biological activities of Ficus species #Pregnane X receptor #Transcription factor

paper · pdf · doi:10.1124/molpharm.123.000725

published in Molecular Pharmacology 105(1), 14-22 (American Society for Pharmacology and Experimental Therapeutics)

openalex publication_date 2023/10/20 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Citations

• Interplay between the Nuclear Receptor Pregnane X Receptor and the Uptake Transporter Organic Anion Transporter Polypeptide 1A2 Selectively Enhances Estrogen Effects in Breast Cancer
• St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

Cited by

• St. John's Wort Extract Increases Pgp Expression in the Brain but Not in the Small Intestine or the Liver of Wistar Rats. [europepmc]