Function of RNase H in DNA replication revealed by RNase H defective mutants of Escherichia coli

1984/02/01 by Tohru Ogawa, Tuneko Okazaki · 26 citations
Biochemistry, Genetics and Molecular Biology · Chemistry · #Biology #Cancer therapeutics and mechanisms #Chemistry #ColE1 #Control of chromosome duplication #DNA #DNA Repair Mechanisms #DNA and Nucleic Acid Chemistry #DNA polymerase #DNA polymerase I #DNA replication #Escherichia coli #Exonuclease #Gene #Genetics #Molecular biology #Mutagenesis #Mutant #Plasmid #Primer (cosmetics) #RNA #RNase H #RNase MRP #RNase P #Replication factor C #Reverse transcriptase

paper · doi:10.1007/bf00330673

openalex publication_date 1984/02/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/25

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• The Impact of RNA-DNA Hybrids on Genome Integrity in Bacteria
• The Crithidia fasciculata RNH1 gene encodes both nuclear and mitochondrial isoforms of RNase H. [europepmc]
• Evolution of ribonuclease H genes in prokaryotes to avoid inheritance of redundant genes. [europepmc]
• Depletion of RNase HI activity in Escherichia coli lacking DNA topoisomerase I leads to defects in DNA supercoiling and segregation. [europepmc]
• Cas3 stimulates runaway replication of a ColE1 plasmid in Escherichia coli and antagonises RNaseHI. [europepmc]
• Transcriptional pathways associated with the slow growth phenotype of transformed Anaplasma marginale. [europepmc]
• Ribonucleotides in bacterial DNA. [europepmc]
• Conformational preferences underlying reduced activity of a thermophilic ribonuclease H. [europepmc]
• The deletion of rnhB in Mycobacterium smegmatis does not affect the level of RNase HII substrates or influence genome stability. [europepmc]
• Interaction with Single-stranded DNA-binding Protein Stimulates Escherichia coli Ribonuclease HI Enzymatic Activity. [europepmc]
• Contribution of reactive oxygen species to thymineless death in Escherichia coli. [europepmc]
• Substrate Specificity for Bacterial RNases HII and HIII Is Influenced by Metal Availability. [europepmc]
• DNA Ligase C and Prim-PolC participate in base excision repair in mycobacteria. [europepmc]
• Replication Rapidly Recovers and Continues in the Presence of Hydroxyurea in Escherichia coli. [europepmc]
• Dna2 processes behind the fork long ssDNA flaps generated by Pif1 and replication-dependent strand displacement. [europepmc]
• RNase HIII Is Important for Okazaki Fragment Processing in Bacillus subtilis . [europepmc]
• DNA Replication Through Strand Displacement During Lagging Strand DNA Synthesis in Saccharomyces cerevisiae . [europepmc]
• Bacterial ribonucleases and their roles in RNA metabolism. [europepmc]
• Interaction with single-stranded DNA-binding protein localizes ribonuclease HI to DNA replication forks and facilitates R-loop removal. [europepmc]
• Restriction endonucleases that cleave RNA/DNA heteroduplexes bind dsDNA in A-like conformation. [europepmc]
• Bulk and single-molecule analysis of a bacterial DNA2-like helicase-nuclease reveals a single-stranded DNA looping motor. [europepmc]
• The Impact of RNA-DNA Hybrids on Genome Integrity in Bacteria. [europepmc]
• Bacillus subtilis encodes a discrete flap endonuclease that cleaves RNA-DNA hybrids. [europepmc]
• Synthetic lethal mutants in Escherichia coli define pathways necessary for survival with RNase H deficiency. [europepmc]
• Molecular insights into the prototypical single-stranded DNA-binding protein from E. coli . [europepmc]
• Identification of pathways required for Salmonella to colonize alfalfa using TraDIS- Xpress . [europepmc]