Myocardial ketone body utilization in patients with heart failure: The impact of oral ketone ester

2020/11/26 by Luca Monzo, Kamil Sedláček, Kamil Sedlacek +9 · 26 citations
Medicine · Biochemistry, Genetics and Molecular Biology · #Diet and metabolism studies #Cardiovascular Function and Risk Factors #Metabolism and Genetic Disorders

paper · doi:10.1016/j.metabol.2020.154452

Cited by

• Acute Echocardiographic Effects of Exogenous Ketone Administration in Healthy Participants
• Cardiac Energy Metabolism in Heart Failure. [europepmc]
• Acute Echocardiographic Effects of Exogenous Ketone Administration in Healthy Participants. [europepmc]
• Low Carbohydrate Diets for Diabetic Cardiomyopathy: A Hypothesis. [europepmc]
• Targeting Myocardial Substrate Metabolism in the Failing Heart: Ready for Prime Time? [europepmc]
• Mitochondria-Mediated Cardiovascular Benefits of Sodium-Glucose Co-Transporter 2 Inhibitors. [europepmc]
• Metformin treatment is associated with improved outcome in patients with diabetes and advanced heart failure (HFrEF). [europepmc]
• Disturbed Cardiac Metabolism Triggers Atrial Arrhythmogenesis in Diabetes Mellitus: Energy Substrate Alternate as a Potential Therapeutic Intervention. [europepmc]
• Neonatal ketone body elevation regulates postnatal heart development by promoting cardiomyocyte mitochondrial maturation and metabolic reprogramming. [europepmc]
• Myocardial Metabolism in Heart Failure. [europepmc]
• Ketones and the Heart: Metabolic Principles and Therapeutic Implications. [europepmc]
• Circulating metabolic signatures of heart failure in precision cardiology. [europepmc]
• The Different Pathways of Epicardial Adipose Tissue across the Heart Failure Phenotypes: From Pathophysiology to Therapeutic Target. [europepmc]
• Ketone ester supplementation suppresses cardiac inflammation and improves cardiac energetics in a swine model of acute myocardial infarction. [europepmc]
• Stimulation of the Hydroxycarboxylic Acid Receptor 2 With the Ketone Body 3-Hydroxybutyrate and Niacin in Patients With Chronic Heart Failure: Hemodynamic and Metabolic Effects. [europepmc]
• A randomized, open-label, parallel pilot study investigating metabolic product kinetics of the novel ketone ester, bis-hexanoyl (R)-1,3-butanediol, over one week of ingestion in healthy adults. [europepmc]
• Metabolic Approaches for the Treatment of Dilated Cardiomyopathy. [europepmc]
• Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility. [europepmc]
• The therapeutic potential of ketones in cardiometabolic disease: impact on heart and skeletal muscle. [europepmc]
• Circulating 3-hydroxy butyrate predicts mortality in patients with chronic heart failure with reduced ejection fraction. [europepmc]
• Cardiovascular Effects of Oral Ketone Ester Treatment in Patients With Heart Failure With Reduced Ejection Fraction: A Randomized, Controlled, Double-Blind Trial. [europepmc]
• Enantiomer-Specific Cardiovascular Effects of the Ketone Body 3-Hydroxybutyrate. [europepmc]
• Nutritional Considerations During Major Weight Loss Therapy: Focus on Optimal Protein and a Low-Carbohydrate Dietary Pattern. [europepmc]
• Human cardiac metabolism. [europepmc]
• Leveraging metabolism for better outcomes in heart failure. [europepmc]
• SGLT2 inhibition alters substrate utilization and mitochondrial redox in healthy and failing rat hearts. [europepmc]