Diagnosis and Management of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome

2023/10/01 by Stephanie L. Grach, Jaime Seltzer, J. L. Seltzer +2 · 1 voice · 103 citations
Medicine · #Chronic fatigue syndrome #Coronavirus disease 2019 (COVID-19) #Disease #Encephalomyelitis #Fibromyalgia and Chronic Fatigue Syndrome Research #Immunology #Infectious disease (medical specialty) #Intensive care medicine #Long-Term Effects of COVID-19 #Medicine #Multiple sclerosis #Musculoskeletal pain and rehabilitation #Pathology #Physical therapy

paper · pdf · doi:10.1016/j.mayocp.2023.07.032

published in Mayo Clinic Proceedings 98(10), 1544-1551 (Elsevier BV)

openalex publication_date 2023/10/01 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a chronic neurologic disease often preceded by infection. There has been increased interest in ME/CFS recently because of its significant overlap with the post-COVID syndrome (long COVID or post-acute sequelae of COVID), with several studies estimating that half of patients with post-COVID syndrome fulfill ME/CFS criteria. Our concise review describes a generalist approach to ME/CFS, including diagnosis, evaluation, and management strategies.

Citations

• The Health-Related Quality of Life for Patients with Myalgic Encephalomyelitis / Chronic Fatigue Syndrome (ME/CFS)
• Caring for the Patient with Severe or Very Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
• Long COVID: major findings, mechanisms and recommendations

Cited by

• Persistent Cerebral 18-FDG PET Changes in Patients With Long COVID Presenting With Fatigue and Post Exertional Malaise
• A Signal for Voice and Speech Abnormalities in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
• Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome
• Alterations in gut microbiota and associated metabolites in patients with chronic fatigue syndrome
• Overlapping conditions in Long COVID at a multisite academic center
• Designing and optimizing clinical trials for long COVID
• Effectiveness and safety of exercise therapy in patients with myalgic encephalomyelitis/chronic fatigue syndrome: a meta-analysis
• Multidisciplinary collaborative guidance on the assessment and treatment of patients with Long COVID : A compendium statement
• Focus on post-exertional malaise when approaching ME/CFS in specialist healthcare improves satisfaction and reduces deterioration. [europepmc]
• Clinical evidence of the link between gut microbiome and myalgic encephalomyelitis/chronic fatigue syndrome: a retrospective review. [europepmc]
• [Interdisciplinary, collaborative D-A-CH (Germany, Austria and Switzerland) consensus statement concerning the diagnostic and treatment of myalgic encephalomyelitis/chronic fatigue syndrome]. [europepmc]
• Quantitative and Longitudinal Assessment of Systemic Innate Immunity in Health and Disease Using a 2D Gene Model. [europepmc]
• Classification Accuracy and Description of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome in an Integrated Health Care System, 2006-2017. [europepmc]
• Patients as knowledge partners in the context of complex chronic conditions. [europepmc]
• Impact of COVID-19 on myalgic encephalomyelitis/chronic fatigue syndrome-like illness prevalence: A cross-sectional survey. [europepmc]
• Long COVID and hypermobility spectrum disorders have shared pathophysiology. [europepmc]
• Immunometabolic changes and potential biomarkers in CFS peripheral immune cells revealed by single-cell RNA sequencing. [europepmc]
• Experiences of physiotherapists working with adults living with Long COVID in Canada: a qualitative study. [europepmc]
• Overlapping conditions in Long COVID at a multisite academic center. [europepmc]
• Crohn's disease, irritable bowel syndrome, and chronic fatigue: the importance of communication and symptom management-a case report. [europepmc]
• Tetrahydrobiopterin in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Friend or Foe? [europepmc]
• Efficacy and safety of Xiaoyao San in the treatment of chronic fatigue syndrome: a systematic review and meta-analysis. [europepmc]
• Advocating the role of trained immunity in the pathogenesis of ME/CFS: a mini review. [europepmc]
• Multidisciplinary collaborative guidance on the assessment and treatment of patients with Long COVID: A compendium statement. [europepmc]
• Evaluating the Causal Role of Genetically Inferred Immune Cells and Inflammatory Cytokines on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome. [europepmc]
• Elevated adipokines and myokines are associated with fatigue in long COVID patients. [europepmc]
• Extracellular vesicle proteomics uncovers energy metabolism, complement system, and endoplasmic reticulum stress response dysregulation postexercise in males with myalgic encephalomyelitis/chronic fatigue syndrome. [europepmc]
• Alterations in gut microbiota and associated metabolites in patients with chronic fatigue syndrome. [europepmc]
• Gut Microbiome and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): Insights into Disease Mechanisms. [europepmc]
• Shared autonomic phenotype of long COVID and myalgic encephalomyelitis/chronic fatigue syndrome. [europepmc]
• Investigating the ME/CFS experience through qualitative analysis of memorial entries. [europepmc]
• Persistent Cerebral 18-FDG PET Changes in Patients With Long COVID Presenting With Fatigue and Post Exertional Malaise. [europepmc]
• The Potential Role of Camel Milk in Alleviating Chronic Fatigue Syndrome in Mice: A Network Pharmacology and In Vivo Validation Study. [europepmc]

Discussions

• Nieuw MayoClinic ME/CVS is een chronische neurologische ziekte veelal voorafgegaan door een infectie. Which produces a “lower quality of life on average than MS, chronic kidney failure, or conges [bsky, 3 points, 0 comments]

Related

• Review of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: an evidence-based approach to diagnosis and management by clinicians
• A Comprehensive Examination of Severely Ill ME/CFS Patients
• Multi-Site Clinical Assessment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (MCAM): Design and Implementation of a Prospective/Retrospective Rolling Cohort Study
• Myalgische Enzephalomyelitis/chronisches Fatigue-Syndrom: eine Übersicht zur aktuellen Evidenz
• Patient-reported treatment outcomes in ME/CFS and long COVID