mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity

2026/06/08 by Yang Luo, Yaofeng Zhong, Sudipto Basu +2 · 1 voice
Biochemistry, Genetics and Molecular Biology · #RNA and protein synthesis mechanisms #RNA Research and Splicing #RNA modifications and cancer

paper · doi:10.1016/j.cell.2026.05.017

Citations

• Intermolecular 3′UTR-3′UTR interactions drive Wnt gene activation through heteromeric protein assembly
• Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate

Discussions

• "We show here that the protein sequence is insufficient for the biogenesis of fully active IDR-containing transcriptional regulators in cells, suggesting that mRNA 3′ UTRs control their activity by pr [bsky, 15 points, 1 comments]