Modular organization as a basis for the functional integration/segregation in large-scale brain networks

2009/01/12 by Valencia, M., Pastor, M. A., Fernandez-Seara, MA. +3
#Biological Physics (physics.bio-ph) #Data Analysis #FOS: Biological sciences #FOS: Physical sciences #Neurons and Cognition (q-bio.NC) #Statistics and Probability (physics.data-an)

paper · doi:10.48550/arxiv.0901.1605

Abstract

Modular structure is ubiquitous among real-world networks from related proteins to social groups. Here we analyze the modular organization of brain networks at a large-scale (voxel level) extracted from functional magnetic resonance imaging (fMRI) signals. By using a random walk-based method, we unveil the modularity of brain-webs, and show that modules with a spatial distribution that matches anatomical structures with functional significance. The functional role of each node in the network is studied by analyzing its patterns of inter- and intra-modular connections. Results suggest that the modular architecture constitutes the structural basis for the coexistence of functional integration of distant and specialized brain areas during normal brain activities at rest.

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