2007/05/29 by Brian N. Lundstrom, Brian Nils Lundstrom, Lundstrom, Brian Nils +6
Biochemistry, Genetics and Molecular Biology · Neuroscience · Physics and Astronomy · #Force Microscopy Techniques and Applications #Neural dynamics and brain function #physics.bio-ph #q-bio.NC #stochastic dynamics and bifurcation
paper · pdf · doi:10.48550/arxiv.0705.4316
18 pages, 5 figures, accepted version
arxiv created 2007/07/16 · arxiv updated 2009/12/01
Recent in vitro data show that neurons respond to input variance with varying sensitivities. Here, we demonstrate that Hodgkin-Huxley (HH) neurons can operate in two computational regimes, one that is more sensitive to input variance (differentiating) and one that is less sensitive (integrating). A boundary plane in the 3D conductance space separates these two regimes. For a reduced HH model, this plane can be derived analytically from the V nullcline, thus suggesting a means of relating biophysical parameters to neural computation by analyzing the neuron's dynamical system.