Association of Benign Paroxysmal Positional Vertigo with Depression and Anxiety—A Systematic Review and Meta‐Analysis

2023/08/10 by Brian Sheng Yep Yeo, Emma Min Shuen Toh, Nicholas E‐Kai Lim +6 · 27 citations
Medicine · Neuroscience · Psychology · #Anxiety #Beck Anxiety Inventory #Beck Depression Inventory #Benign paroxysmal positional vertigo #Cochrane Library #Depression (economics) #Internal medicine #Medicine #Meta-analysis #Multisensory perception and integration #Observational study #Physical therapy #Population #Psychiatry #Randomized controlled trial #Respiratory and Cough-Related Research #Surgery #Vertigo #Vestibular and auditory disorders

paper · pdf · doi:10.1002/lary.30957

published in The Laryngoscope 134(2), 526-534 (Wiley)

openalex publication_date 2023/08/10 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/28

Abstract

OBJECTIVE: To evaluate the extent to which Benign Paroxysmal Positional Vertigo (BPPV) is associated with a higher prevalence of depression and anxiety in patients. DATA SOURCES: Three databases including PubMed, Embase, and The Cochrane Library were searched by two independent authors from inception to June 12, 2022 for observational studies and randomized controlled trials investigating the association between BPPV and depression and anxiety. We included studies published as full-length articles in peer-reviewed journals with an adult population aged at least 18 years who have BPPV, detected through validated clinical methods like clinical diagnosis, interview and Dix-Hallpike test. RESULTS: A total of 23 articles met the final inclusion criteria and 19 articles were included in the meta-analysis. BPPV was associated with a 3.19 increased risk of anxiety compared to controls, and 27% (17%-39%) of BPPV patients suffered from anxiety. Furthermore, the weighted average Beck's Anxiety Inventory score was 18.38 (12.57; 24.18), while the weighted average State-Trait Anxiety Index score was 43.08 (37.57; 48.60). CONCLUSION: There appears to be some association between BPPV and anxiety, but further studies are required to confirm these associations. Laryngoscope, 134:526-534, 2024.

Citations

• Symptoms, anxiety and handicap in dizzy patients: Development of the Vertigo symptom scale

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• Living With the Fear of Recurrence in Benign Paroxysmal Positional Vertigo. [europepmc]
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• Unnecessary magnetic resonance imaging is associated with diagnostic delay and financial burden in benign paroxysmal positional vertigo: a retrospective study in Mongolia. [europepmc]
• Brain fMRI study in elderly BPPV patients with comorbid anxiety and depression. [europepmc]
• Serum neurotransmitter imbalances in benign paroxysmal positional vertigo: correlations with anxiety, depression, and sleep quality. [europepmc]
• Development and temporal validation of an interpretable prediction model for delayed diagnosis of benign paroxysmal positional vertigo: a retrospective study from Beijing, China [europepmc]

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