Axonal Transport Enables Neuron-to-Neuron Propagation of Human Coronavirus OC43

2018/06/15 by Mathieu Dubé, Alain Le Coupanec, Alan H. M. Wong +3 · 470 citations
Agricultural and Biological Sciences · Medicine · Neuroscience · #Animal Virus Infections Studies #Biology #Central nervous system #Coronavirus #Coronavirus disease 2019 (COVID-19) #Disease #Long-Term Effects of COVID-19 #Medicine #Neuron #Neuroscience #Olfactory bulb #Pathology #SARS-CoV-2 and COVID-19 Research #Virology

paper · doi:10.1128/jvi.00404-18

published in Journal of Virology 92(17) (American Society for Microbiology)

openalex publication_date 2018/06/15 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06

Abstract

Coronaviruses may invade the CNS, disseminate, and participate in the induction of neurological diseases. Their neuropathogenicity is being increasingly recognized in humans, and the presence and persistence of human coronaviruses (HCoV) in human brains have been proposed to cause long-term sequelae. Using our mouse model relying on natural susceptibility to HCoV OC43 and neuronal cell cultures, we have defined the most relevant path taken by HCoV OC43 to access and spread to and within the CNS toward the brain stem and spinal cord and studied in cell culture the underlying modes of intercellular propagation to better understand its neuropathogenesis. Our data suggest that axonal transport governs HCoV OC43 egress in the CNS, leading to the exacerbation of neuropathogenesis. Exploiting knowledge on neuroinvasion and dissemination will enhance our ability to control viral infection within the CNS, as it will shed light on underlying mechanisms of neuropathogenesis and uncover potential druggable molecular virus-host interfaces.

Citations

• Characterization of a Novel Coronavirus Associated with Severe Acute Respiratory Syndrome

Cited by

• Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines
• Current status and future perspectives on the mechanistic and pathophysiological understanding of long COVID
• Neuroinflammation in Post COVID‐19 Sequelae: Neuroinvasion and Neuroimmune Crosstalk
• Infectivity of human coronavirus in the brain
• Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System? [europepmc]
• The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients. [europepmc]
• Neuroinfection may contribute to pathophysiology and clinical manifestations of COVID-19. [europepmc]
• COVID-19: A promising cure for the global panic. [europepmc]
• Neurotropism of SARS-CoV 2: Mechanisms and manifestations. [europepmc]
• Multidisciplinary research priorities for the COVID-19 pandemic: a call for action for mental health science. [europepmc]
• Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection. [europepmc]
• Neurological manifestations of COVID-19 and other coronavirus infections: A systematic review. [europepmc]
• Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019: A Review. [europepmc]
• Spectrum of neuropsychiatric manifestations in COVID-19. [europepmc]
• Evolution of Altered Sense of Smell or Taste in Patients With Mildly Symptomatic COVID-19. [europepmc]
• COVID-19 and the Chemical Senses: Supporting Players Take Center Stage. [europepmc]
• Neurological complications of coronavirus infection; a comparative review and lessons learned during the COVID-19 pandemic. [europepmc]
• Effects of COVID-19 on the Nervous System. [europepmc]
• Anosmia in COVID-19: Underlying Mechanisms and Assessment of an Olfactory Route to Brain Infection. [europepmc]
• Neuromuscular presentations in patients with COVID-19. [europepmc]
• Human Pluripotent Stem Cell-Derived Neural Cells and Brain Organoids Reveal SARS-CoV-2 Neurotropism Predominates in Choroid Plexus Epithelium. [europepmc]
• Long-Term Respiratory and Neurological Sequelae of COVID-19. [europepmc]
• Neuroinvasion and Encephalitis Following Intranasal Inoculation of SARS-CoV-2 in K18-hACE2 Mice. [europepmc]
• Slow but Evident Recovery from Neocortical Dysfunction and Cognitive Impairment in a Series of Chronic COVID-19 Patients. [europepmc]
• Cognitive impairment and altered cerebral glucose metabolism in the subacute stage of COVID-19. [europepmc]
• Cognitive impairments four months after COVID-19 hospital discharge: Pattern, severity and association with illness variables. [europepmc]
• Fluvoxamine: A Review of Its Mechanism of Action and Its Role in COVID-19. [europepmc]
• Emerging COVID-19 variants and their impact on SARS-CoV-2 diagnosis, therapeutics and vaccines. [europepmc]
• Non-cell-autonomous disruption of nuclear architecture as a potential cause of COVID-19-induced anosmia. [europepmc]

Related

• Neuroinvasion by Human Respiratory Coronaviruses
• Infectivity of human coronavirus in the brain
• Monkeypox virus spreads from cell-to-cell and leads to neuronal death in human neural organoids
• Neuroinvasion of SARS-CoV-2 in human and mouse brain
• Viruses and neurodegeneration