Clade 2.3.4.4b highly pathogenic avian influenza H5N1 viruses: knowns, unknowns, and challenges

2025/05/09 by Zimin Xie, Jiayun Yang, Wanlin Jiao +4 · 46 citations
Agricultural and Biological Sciences · Medicine · #Animal Disease Management and Epidemiology #Avian influenza virus #Biology #Clade #Ecology #Gene #Genetics #Highly pathogenic #Host (biology) #Influenza A virus #Influenza A virus subtype H5N1 #Influenza Virus Research Studies #Outbreak #Phylogenetics #Viral gastroenteritis research and epidemiology #Virology #Virus #Zoology

paper · doi:10.1128/jvi.00424-25

published in Journal of Virology 99(6), e0042425 (American Society for Microbiology)

openalex publication_date 2025/05/09 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/04

Abstract

Since 2020, the clade 2.3.4.4b highly pathogenic avian influenza (HPAI) H5N1 viruses have caused unprecedented outbreaks in wild birds and domestic poultry globally, resulting in significant ecological damage and economic losses due to the disease and enforced stamp-out control. In addition to the avian hosts, the H5N1 viruses have expanded their host range to infect many mammalian species, potentially increasing the zoonotic risk. Here, we review the current knowns and unknowns of clade 2.3.4.4b HPAI H5N1 viruses, and we highlight common challenges in prevention. By integrating our knowledge of viral evolution and ecology, we aim to identify discrepancies and knowledge gaps for a more comprehensive understanding of the virus. Ultimately, this review will serve as a theoretical foundation for researchers involved in related avian influenza virus studies, aiding in improved control and prevention of H5N1 viruses.

Citations

• Avian influenza A (H5N1) virus in dairy cattle: origin, evolution, and cross-species transmission

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