2006/01/01 by Anders Breinbjerg, Cecilie Siggaard Jørgensen, G. Bragi Walters +24 · 11 citations
Arts and Humanities · Medicine · #Ancient Egypt and Archaeology #Congenital gastrointestinal and neural anomalies #Daytime #Gene #Genetics #Genome-wide association study #Genotype #Gerontology #Language, Linguistics, Cultural Analysis #Medicine #Pelvic floor disorders treatments #Single-nucleotide polymorphism #Urinary Bladder and Prostate Research #Urinary incontinence #Urology
paper · doi:10.1097/ju.0000000000004187
published in The Journal of Urology 212(6), 851-861 (Lippincott Williams & Wilkins)
openalex publication_date 2024/08/02 · openalex created_date 2024/08/03 · openalex updated_date 2026/08/01
PURPOSE: Childhood incontinence is stigmatized and underprioritized, and a basic understanding of its pathogenesis is missing. Our goal was to identify risk-conferring genetic variants in daytime urinary incontinence (DUI). MATERIALS AND METHODS: We conducted a genome-wide association study in the Danish iPSYCH2015 cohort. Cases (3024) were identified through DUI diagnosis codes and redeemed prescriptions for DUI medication in individuals aged 5 to 20 years. Controls (30,240), selected from the same sample, were matched to cases on sex and psychiatric diagnoses, if any, and down-sampled to a 1:10 case:control ratio. Replication was performed in the Icelandic deCODE cohort (5475 cases/287,773 controls). Single-nucleotide polymorphism heritability was calculated using the genome-based restricted maximum likelihood method. Cross-trait genetic correlation was estimated using linkage disequilibrium score regression. Polygenic risk scores generated with LDpred2-auto and BOLT-LMM were assessed for association. RESULTS: < .0001) polygenic risk. CONCLUSIONS: Common genetic variants contribute to the risk of childhood DUI, and genes important in neuronal development and detrusor smooth muscle activity were implicated. These findings may help guide identification of new treatment targets.