2017/02/08 by Jacques M. Bahi, Christophe Guyeux, Bahi, Jacques M. +3
Biochemistry, Genetics and Molecular Biology · #FOS: Biological sciences #Fungal and yeast genetics research #Genomics and Chromatin Dynamics #Populations and Evolution (q-bio.PE) #RNA and protein synthesis mechanisms
paper · pdf · doi:10.48550/arxiv.1702.02879
openalex publication_date 2017/02/08 · openalex created_date 2022/10/02 · openalex updated_date 2026/07/28
Since the late `60s, various genome evolutionary models have been proposed to\npredict the evolution of a DNA sequence as the generations pass. Most of these\nmodels are based on nucleotides evolution, so they use a mutation matrix of\nsize 4x4. They encompass for instance the well-known models of Jukes and\nCantor, Kimura, and Tamura. By essence, all of these models relate the\nevolution of DNA sequences to the computation of the successive powers of a\nmutation matrix. To make this computation possible, particular forms for the\nmutation matrix are assumed, which are not compatible with mutation rates that\nhave been recently obtained experimentally on gene ura3 of the Yeast\nSaccharomyces cerevisiae. Using this experimental study, authors of this paper\nhave deduced a simple mutation matrice, compute the future evolution of the\nrate purine/pyrimidine for ura3, investigate the particular behavior of\ncytosines and thymines compared to purines, and simulate the evolution of each\nnucleotide.\n