2015/07/06 by Mansoureh Tajaddod, Michael F. Jantsch, Konstantin Licht · 1 citation
Biochemistry, Genetics and Molecular Biology · Medicine · #RNA regulation and disease #Cytomegalovirus and herpesvirus research #CRISPR and Genetic Engineering
paper · pdf · doi:10.1007/s00412-015-0526-9
Adenosine to inosine editing (A to I editing) is a cotranscriptional process that contributes to transcriptome complexity by deamination of adenosines to inosines. Initially, the impact of A to I editing has been described for coding targets in the nervous system. Here, A to I editing leads to recoding and changes of single amino acids since inosine is normally interpreted as guanosine by cellular machines. However, more recently, new roles for A to I editing have emerged: Editing was shown to influence splicing and is found massively in Alu elements. Moreover, A to I editing is required to modulate innate immunity. We summarize the multiple ways in which A to I editing generates transcriptome variability and highlight recent findings in the field.