The dynamic epitranscriptome: A to I editing modulates genetic information

2015/07/06 by Mansoureh Tajaddod, Michael F. Jantsch, Konstantin Licht · 38 citations
Biochemistry, Genetics and Molecular Biology · Medicine · #Adenosine #Alu element #Biology #CRISPR #CRISPR and Genetic Engineering #Computational biology #Cytomegalovirus and herpesvirus research #Gene #Gene expression #Genetics #Genome #Genome editing #Guanosine #Human genome #Inosine #Intron #RNA editing #RNA regulation and disease #Transcriptome

paper · pdf · doi:10.1007/s00412-015-0526-9

published in Chromosoma 125(1), 51-63 (Springer Science+Business Media)

openalex publication_date 2015/07/06 · openalex created_date 2025/10/10 · openalex updated_date 2026/07/31

Abstract

Adenosine to inosine editing (A to I editing) is a cotranscriptional process that contributes to transcriptome complexity by deamination of adenosines to inosines. Initially, the impact of A to I editing has been described for coding targets in the nervous system. Here, A to I editing leads to recoding and changes of single amino acids since inosine is normally interpreted as guanosine by cellular machines. However, more recently, new roles for A to I editing have emerged: Editing was shown to influence splicing and is found massively in Alu elements. Moreover, A to I editing is required to modulate innate immunity. We summarize the multiple ways in which A to I editing generates transcriptome variability and highlight recent findings in the field.

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