2025/10/31 by Ali Samii Moghaddam, Morteza Mooziri, Mohammad Reza Raoufy +1 · 1 voice
Neuroscience · #Cognition #Coupling (piping) #Local field potential #Memory and Neural Mechanisms #Neural activity #Neural dynamics and brain function #Olfactory and Sensory Function Studies #Olfactory bulb #Prefrontal cortex #Sensory system #Working memory
paper · pdf · doi:10.1101/2025.10.30.685257
published in bioRxiv (Cold Spring Harbor Laboratory) (Cold Spring Harbor Laboratory)
openalex created_date 2025/10/31 · openalex publication_date 2025/10/31 · openalex updated_date 2026/07/14
Abstract Working memory (WM), the ability to maintain task-related information, is fundamental to animal behaviors. Despite significance, there is limited knowledge on how it is orchestrated by the neural activity in the brain. Here, we show that the olfactory bulb (OB) and medial prefrontal cortex (mPFC) slow oscillations (1-30 Hz) are augmented during WM, and furthermore, the pattern of these activities convey task-related information. Moreover, we find that the OB-mPFC delta and beta power-based connectivity is enhanced by WM. On the other hand, theta oscillations have the most prominent roles in phase coupling in this circuit. We also show bidirectional information transfer, stronger in the mPFC-to-OB direction, between the two brain areas. Furthermore, during WM, beta activity in both regions is tuned by the phase of local and long-range delta as well as theta oscillations. Together, our results suggest that the dynamics of OB-mPFC circuit slow band activities underlies WM, with possible implications for other cognitive functions in health and disease.