Multiple overlapping binding sites determine transcription factor occupancy

2025/09/03 by Shubham Khetan, Brent S. Carroll, Martha L. Bulyk · 1 voice · 7 citations
Biochemistry, Genetics and Molecular Biology · #Biology #Computational biology #Ecology #Gene #Genetics #Genomics and Chromatin Dynamics #Occupancy #RNA Research and Splicing #RNA modifications and cancer #Transcription factor

paper · doi:10.1038/s41586-025-09472-3

openalex publication_date 2025/09/03 · openalex created_date 2025/10/10 · openalex updated_date 2026/08/06

Cited by

• Pervasive Transcription in the Human Genome Exceeds Background Noise
• How to build the regulatory genome: a constructionist guide to the cis-regulatory code
• A principled approach to the identification of biologically relevant transcription factor binding sites
• Decoding RNA-protein interactions using high-throughput methods. [europepmc]
• Pervasive Transcription in the Human Genome Exceeds Background Noise. [europepmc]
• Trans-acting Determinants of Gene Expression: Effects of Transcription Factor Affinity, Abundance, and Localization [europepmc]
• GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factors [europepmc]

Discussions

• I suspected this during my first postdoc, when I was working with snATAC-seq data. Nice to see people doing the hard work! Multiple overlapping binding sites determine #transcription factor occupancy [bsky, 14 points, 0 comments]