2020/10/31 by Kirill Efimov, Efimov, Kirill V., Alina Tetereva +7
Neuroscience · #FOS: Biological sciences #Functional Brain Connectivity Studies #Memory and Neural Mechanisms #Neural and Behavioral Psychology Studies #Neurons and Cognition (q-bio.NC)
paper · pdf · doi:10.48550/arxiv.2011.00257
openalex publication_date 2020/10/31 · openalex created_date 2022/07/25 · openalex updated_date 2026/07/28
The analysis of the functional connectivity of brain sections associated with\nfear-conditioned training is one of the methods of study of memory neural\nnetworks. Before, the majority of studies focused on the functional\nconnectivity of the brain regions that are known for emotional processing such\nas amygdala and areas of the ventromedial prefrontal cortex in the resting\nstate right after the formation of a fear-conditioned reflex. In the present\nstudy authors applied the methods of the theory of graphs to search for changes\nin the functional connectivity at the level of the brain in the resting state\nin a week dynamics after the extinction of a conditioned reflex with partial\nreinforcement. The most significant changes were observed in the functional\nconnectivity of the left parahippocampal area. In particular, the rostral part\nof the left parahippocampal gyrus became the center of a new subnetwork\nconnected with the rostral part of the left hippocampus in all the sessions and\nafter the extinction of a conditioned reflex and the lateral part of the left\namygdala right after the extinction and a day after the extinction of a\nconditioned reflex. A week after the extinction of a conditioned reflex, the\nrostral part of the left parahippocampal gyrus also had more connections with\nthe areas of the middle frontal gyrus in comparison with the parameters of the\nbaseline resting state to the stimulus. Besides, these changes remained within\none week from the moment of the extinction of a conditioned reflex, which could\nbe explained by the chosen paradigm of conditioned reflex with partial\nreinforcement that led to a slower extinction than a paradigm with full\nreinforcement.\n