Establishing Transcriptional Signatures to Differentiate PXR-, CAR-, and AhR-Mediated Regulation of Drug Metabolism and Transport Genes in Cryopreserved Human Hepatocytes

2018/02/12 by Jamie E. Moscovitz, Amit S. Kalgutkar, Kelly Nulick +4 · 24 citations
Pharmacology, Toxicology and Pharmaceutics · Medicine · #Pharmacogenetics and Drug Metabolism #Drug Transport and Resistance Mechanisms #Hormonal Regulation and Hypertension

paper · pdf · doi:10.1124/jpet.117.247296

Citations

• FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity

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