A Selective Small Molecule IκB Kinase β Inhibitor Blocks Nuclear Factor κB-Mediated Inflammatory Responses in Human Fibroblast-Like Synoviocytes, Chondrocytes, and Mast Cells

2006/03/09 by Danyi Wen, Yuhua Nong, Jennifer G. Morgan +13 · 25 citations
Biochemistry, Genetics and Molecular Biology · Immunology and Microbiology · #NF-κB Signaling Pathways #Immune Response and Inflammation #Antimicrobial Peptides and Activities

paper · doi:10.1124/jpet.105.097584

Cited by

• Developments in the synovial biology field 2006. [europepmc]
• Advances in targeting IKK and IKK-related kinases for cancer therapy. [europepmc]
• Targeting the NF-kappaB pathway in asthma and chronic obstructive pulmonary disease. [europepmc]
• B-cell-derived lymphotoxin promotes castration-resistant prostate cancer. [europepmc]
• Hepatocyte IKKbeta/NF-kappaB inhibits tumor promotion and progression by preventing oxidative stress-driven STAT3 activation. [europepmc]
• I-kappa-kinase-2 (IKK-2) inhibition potentiates vincristine cytotoxicity in non-Hodgkin's lymphoma. [europepmc]
• Sensitization of tumor cells to cancer therapy by molecularly targeted inhibition of the inhibitor of nuclear factor κB kinase. [europepmc]
• Targeting the NF-κB and mTOR pathways with a quinoxaline urea analog that inhibits IKKβ for pancreas cancer therapy. [europepmc]
• Pentacyclic Triterpenoids Inhibit IKKβ Mediated Activation of NF-κB Pathway: In Silico and In Vitro Evidences. [europepmc]
• Isatin Derived Spirocyclic Analogues with α-Methylene-γ-butyrolactone as Anticancer Agents: A Structure-Activity Relationship Study. [europepmc]
• Long-acting β 2 -agonists promote glucocorticoid-mediated repression of NF-κB by enhancing expression of the feedback regulator TNFAIP3. [europepmc]
• Protective effects of Nebivolol against interleukin-1β (IL-1β)-induced type II collagen destruction mediated by matrix metalloproteinase-13 (MMP-13). [europepmc]
• Inhibitory Kappa B Kinase α (IKKα) Inhibitors That Recapitulate Their Selectivity in Cells against Isoform-Related Biomarkers. [europepmc]
• The p55TNFR-IKK2-Ripk3 axis orchestrates arthritis by regulating death and inflammatory pathways in synovial fibroblasts. [europepmc]
• Role of Toll-Like Receptor 4 on Osteoblast Metabolism and Function. [europepmc]
• IL1-Induced JAK/STAT Signaling Is Antagonized by TGFβ to Shape CAF Heterogeneity in Pancreatic Ductal Adenocarcinoma. [europepmc]
• Latent, Immunosuppressive Nature of Poly(lactic- co -glycolic acid) Microparticles. [europepmc]
• Tumour-Derived Laminin α5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition. [europepmc]
• Procyanidin A1 Alleviates Inflammatory Response induced by LPS through NF-κB, MAPK, and Nrf2/HO-1 Pathways in RAW264.7 cells. [europepmc]
• The Role of NF-κB in Physiological Bone Development and Inflammatory Bone Diseases: Is NF-κB Inhibition "Killing Two Birds with One Stone"? [europepmc]
• Breaking the vicious loop between inflammation, oxidative stress and coagulation, a novel anti-thrombus insight of nattokinase by inhibiting LPS-induced inflammation and oxidative stress. [europepmc]
• Comprehensive Mapping of Key Regulatory Networks that Drive Oncogene Expression. [europepmc]
• Structure activity relationship (SAR) study identifies a quinoxaline urea analog that modulates IKKβ phosphorylation for pancreatic cancer therapy. [europepmc]
• VRK2 activates TNFα/NF-κB signaling by phosphorylating IKKβ in pancreatic cancer. [europepmc]
• Costunolide alleviates atherosclerosis in high-fat diet-fed ApoE -/- mice through covalently binding to IKKβ and inhibiting NF-κB-mediated inflammation. [europepmc]