(S)-1-((S)-2-[1-(4-Amino-3-chloro-phenyl)-methanoyl]-amino-3,3-dimethyl-butanoyl)-pyrrolidine-2-carboxylic acid ((2 R,3 S)-2-ethoxy-5-oxo-tetrahydro-furan-3-yl)-amide (VX-765), an Orally Available Selective Interleukin (IL)-Converting Enzyme/Caspase-1 Inhibitor, Exhibits Potent Anti-Inflammatory Activities by Inhibiting the Release of IL-1β and IL-18

2007/02/09 by Woods Wannamaker, Robert Davies, Robert M. D. Davies +14 · 6 citations
Biochemistry, Genetics and Molecular Biology · Medicine · Immunology and Microbiology · #Inflammasome and immune disorders #Autoimmune and Inflammatory Disorders Research #Immune Response and Inflammation

paper · doi:10.1124/jpet.106.111344

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