Activity-Dependent Neuroprotective Protein Snippet NAP Reduces Tau Hyperphosphorylation and Enhances Learning in a Novel Transgenic Mouse Model

2007/08/25 by Inna Vulih-Shultzman, Inna Vulih‐Shultzman, Albert Pinhasov +5 · 25 citations
Biochemistry, Genetics and Molecular Biology · #Ubiquitin and proteasome pathways #ATP Synthase and ATPases Research #Cell death mechanisms and regulation

paper · doi:10.1124/jpet.107.129551

Cited by

• New approaches to the treatment of frontotemporal lobar degeneration. [europepmc]
• A pilot trial of the microtubule-interacting peptide (NAP) in mice overexpressing alpha-synuclein shows improvement in motor function and reduction of alpha-synuclein inclusions. [europepmc]
• Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies. [europepmc]
• The many faces of tau. [europepmc]
• Alzheimer mechanisms and therapeutic strategies. [europepmc]
• Mitochondrial abnormalities in Alzheimer's disease: possible targets for therapeutic intervention. [europepmc]
• A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP. [europepmc]
• Prioritization of neurodevelopmental disease genes by discovery of new mutations. [europepmc]
• The transcriptional regulator ADNP links the BAF (SWI/SNF) complexes with autism. [europepmc]
• New horizons in schizophrenia treatment: autophagy protection is coupled with behavioral improvements in a mouse model of schizophrenia. [europepmc]
• Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers. [europepmc]
• Tau-Centric Targets and Drugs in Clinical Development for the Treatment of Alzheimer's Disease. [europepmc]
• A Subset of Autism-Associated Genes Regulate the Structural Stability of Neurons. [europepmc]
• The Eight and a Half Year Journey of Undiagnosed AD: Gene Sequencing and Funding of Advanced Genetic Testing Has Led to Hope and New Beginnings. [europepmc]
• The Role of the Microtubule Cytoskeleton in Neurodevelopmental Disorders. [europepmc]
• Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome. [europepmc]
• The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse. [europepmc]
• Dual Role of Autophagy in Diseases of the Central Nervous System. [europepmc]
• The autism-mutated ADNP plays a key role in stress response. [europepmc]
• Discovery of autism/intellectual disability somatic mutations in Alzheimer's brains: mutated ADNP cytoskeletal impairments and repair as a case study. [europepmc]
• ADNP promotes neural differentiation by modulating Wnt/β-catenin signaling. [europepmc]
• Tauopathy in the young autistic brain: novel biomarker and therapeutic target. [europepmc]
• Episignatures Stratifying Helsmoortel-Van Der Aa Syndrome Show Modest Correlation with Phenotype. [europepmc]
• Proteomics of autism and Alzheimer's mouse models reveal common alterations in mTOR signaling pathway. [europepmc]
• Modelling Autism Spectrum Disorder (ASD) and Attention-Deficit/Hyperactivity Disorder (ADHD) Using Mice and Zebrafish. [europepmc]