Rational design, expression and refolding of a novel bispecific antibody to simultaneously target VEGF-A and Ang-2 for inhibition of angiogenesis

2026/07/01 by Elahe Pishgahzadeh, Ladan Mafakher, Sara Dabirian +4
Biochemistry, Genetics and Molecular Biology · Medicine · #Angiogenesis and VEGF in Cancer #Monoclonal and Polyclonal Antibodies Research #Microbial metabolism and enzyme function

paper · doi:10.1016/j.xphs.2026.104432

Citations

• Identification of serum angiopoietin-2 as a biomarker for clinical outcome of colorectal cancer patients treated with bevacizumab-containing therapy
• PROCHECK: a program to check the stereochemical quality of protein structures
• Correct protein folding in glycerol
• A kinetic study of the competition between renaturation and aggregation during the refolding of denatured-reduced egg white lysozyme
• Mechanisms of Protein Stabilization and Prevention of Protein Aggregation by Glycerol
• A critical assessment of the impact of mixing on dilution refolding
• Thermal and Chemical Unfolding of a Monoclonal IgG1 Antibody: Application of the Multistate Zimm-Bragg Theory
• Angiopoietin inhibitors: A review on targeting tumor angiogenesis