Review of Disintegrants and the Disintegration Phenomena

2016/02/14 by Parind Mahendrakumar Desai, Parind M. Desai, Celine Valeria Liew +1 · 26 citations
Pharmacology, Toxicology and Pharmaceutics · Materials Science · Medicine · #Drug Solubulity and Delivery Systems #Crystallization and Solubility Studies #Pharmaceutical studies and practices

paper · doi:10.1016/j.xphs.2015.12.019

Cited by

• Pharmaceutical evaluation of plantain peel pectin as a disintegrant in conventional tablets
• Evaluation of the Disintegrant Properties of Native Starches of Five New Cassava Varieties in Paracetamol Tablet Formulations. [europepmc]
• Impact of Superdisintegrants and Film Thickness on Disintegration Time of Strip Films Loaded With Poorly Water-Soluble Drug Microparticles. [europepmc]
• Excipient-drug pharmacokinetic interactions: Effect of disintegrants on efflux across excised pig intestinal tissues. [europepmc]
• Modeling of Disintegration and Dissolution Behavior of Mefenamic Acid Formulation Using Numeric Solution of Noyes-Whitney Equation with Cellular Automata on Microtomographic and Algorithmically Generated Surfaces. [europepmc]
• Multilayer-Coated Tablet of Clopidogrel and Rosuvastatin: Preparation and In Vitro/In vivo Characterization. [europepmc]
• Design, Optimization, and Correlation of In Vitro/In Vivo Disintegration of Novel Fast Orally Disintegrating Tablet of High Dose Metformin Hydrochloride Using Moisture Activated Dry Granulation Process and Quality by Design Approach. [europepmc]
• A Precise Prediction Method for the Properties of API-Containing Tablets Based on Data from Placebo Tablets. [europepmc]
• Formulation of Orally Disintegrating Films as an Amorphous Solid Solution of a Poorly Water-Soluble Drug. [europepmc]
• Enhancing the Low Oral Bioavailability of Sulpiride via Fast Orally Disintegrating Tablets: Formulation, Optimization and In Vivo Characterization. [europepmc]
• Additive Manufacturing of Oral Tablets: Technologies, Materials and Printed Tablets. [europepmc]
• Levothyroxine Therapy in Gastric Malabsorptive Disorders. [europepmc]
• Impact of Critical Material Attributes (CMAs)-Particle Shape on Miniature Pharmaceutical Unit Operations. [europepmc]
• Immediate-Release Formulations Produced via Twin-Screw Melt Granulation: Systematic Evaluation of the Addition of Disintegrants. [europepmc]
• Exploitation of Design-of-Experiment Approach for Design and Optimization of Fast-Disintegrating Tablets for Sublingual Delivery of Sildenafil Citrate with Enhanced Bioavailability Using Fluid-Bed Granulation Technique. [europepmc]
• Potential and Comparative Tablet Disintegrant Properties of Pectin Obtained from Five Okra Genotypes in Ghana. [europepmc]
• Preparation, Properties and Potential of Carrageenan-Based Hard Capsules for Replacing Gelatine: A Review. [europepmc]
• Three-Dimensional Printing of a Container Tablet: A New Paradigm for Multi-Drug-Containing Bioactive Self-Nanoemulsifying Drug-Delivery Systems (Bio-SNEDDSs). [europepmc]
• Classification of scanning electron microscope images of pharmaceutical excipients using deep convolutional neural networks with transfer learning. [europepmc]
• Influences of Glimepiride Self-Nanoemulsifying Drug Delivery System Loaded Liquisolid Tablets on the Hypoglycemic Activity and Pancreatic Histopathological Changes in Streptozotocin-Induced Hyperglycemic Rats. [europepmc]
• Development and Optimization of Sildenafil Orodispersible Mini-Tablets (ODMTs) for Treatment of Pediatric Pulmonary Hypertension Using Response Surface Methodology. [europepmc]
• Characterization and Validation of a New 3D Printing Ink for Reducing Therapeutic Gap in Pediatrics through Individualized Medicines. [europepmc]
• Pharmacotechnical, Physico-Chemical, and Antioxidant Evaluation of Newly Developed Capsule Formulations. [europepmc]
• Fast time-resolved micro-CT imaging of pharmaceutical tablets: Insights into water uptake and disintegration. [europepmc]
• Advanced analysis of disintegrating pharmaceutical compacts using deep learning-based segmentation of time-resolved micro-tomography images. [europepmc]
• Fabrication of Polypill Pharmaceutical Dosage Forms Using Fused Deposition Modeling 3D Printing: A Systematic Review. [europepmc]