Metal-Induced Fatty Acid Particle Formation Resulting from Hydrolytic Polysorbate Degradation

2021/10/01 by Kathrin Gregoritza, Si Kai Cai, Matej Siketanc +7 · 5 citations
Biochemistry, Genetics and Molecular Biology · Materials Science · #Protein purification and stability #Viral Infectious Diseases and Gene Expression in Insects #Crystallization and Solubility Studies

paper · doi:10.1016/j.xphs.2021.09.044

Citations

• Host cell protein impurities in chromatographic polishing steps for monoclonal antibody purification
• Knockout of a difficult‐to‐remove CHO host cell protein, lipoprotein lipase, for improved polysorbate stability in monoclonal antibody formulations

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